FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4230268840> ?p ?o ?g. }

• W4230268840 endingPage "1733" @default.
• W4230268840 startingPage "1728" @default.
• W4230268840 abstract "<b>Background:</b> Pilot studies of interferon α (IFN-α) suggest a high remission rate in the treatment of active ulcerative colitis. We evaluated the safety of pegylated interferon α (PegIFN) and its role in induction of remission in patients with active ulcerative colitis, in a multicentre placebo controlled trial. <b>Methods:</b> Sixty patients with a clinical activity score (CAI) of >6 were randomised to receive placebo (n = 20), PegIFN 0.5 μg/kg (n = 19), or PegIFN 1.0 μg/kg body weight (n = 21) once weekly (PegIntron; Schering-Plough, USA) over 12 weeks. Patients receiving 5-aminosalicylates, steroids, and/or azathioprine in stable dosages were included. <b>Results:</b> Serious adverse events were seen in none of the placebo patients, in 3/19 patients in the PegIFN 0.5 μg/kg group (hospitalisation due to disease flare up n = 3), and in 3/21 in the PegIFN 1.0 μg/kg group (hospitalisation due to disease flare up n = 1; thrombosis n = 1; grand mal seizure n = 1). Otherwise, we observed only minor IFN-α side effects. Clinical remission rates at week 12 (CAI ⩽4) were 7/20 (35%) in the placebo, 9/19 (47%) in the PegIFN 0.5 μg/kg group, and 7/21 (33%) in the PegIFN 1.0 μg/kg group (NS). Early withdrawal from the study was observed in 11/20 placebo patients, in 6/19 in the PegIFN 0.5 μg/kg group, and in 10/21 in the PegIFN 1.0 μg/kg group, mainly due to lack of efficacy. The higher PegIFN dose was associated with a significant decrease in levels of C reactive protein (p = 0.003, day 0 <i>v</i> 85). <b>Conclusions:</b> PegIFN is safe but not effective, at the dosages used, in patients with ulcerative colitis." @default.
• W4230268840 created "2022-05-11" @default.
• W4230268840 creator A5050626665 @default.
• W4230268840 date "2003-12-01" @default.
• W4230268840 modified "2023-10-14" @default.
• W4230268840 title "A randomised placebo controlled trial of pegylated interferon in active ulcerative colitis" @default.
• W4230268840 cites W1515994079 @default.
• W4230268840 cites W1640867939 @default.
• W4230268840 cites W183054515 @default.
• W4230268840 cites W1946093640 @default.
• W4230268840 cites W1965472353 @default.
• W4230268840 cites W1981731179 @default.
• W4230268840 cites W1991872145 @default.
• W4230268840 cites W2000208875 @default.
• W4230268840 cites W2009411287 @default.
• W4230268840 cites W2018954400 @default.
• W4230268840 cites W2022075225 @default.
• W4230268840 cites W2028959153 @default.
• W4230268840 cites W2038428454 @default.
• W4230268840 cites W2049932899 @default.
• W4230268840 cites W2080034594 @default.
• W4230268840 cites W2088988430 @default.
• W4230268840 cites W2102649003 @default.
• W4230268840 cites W2114465053 @default.
• W4230268840 cites W2146906769 @default.
• W4230268840 cites W2166930089 @default.
• W4230268840 cites W2179587148 @default.
• W4230268840 cites W2279160356 @default.
• W4230268840 cites W2411394658 @default.
• W4230268840 cites W4292198229 @default.
• W4230268840 doi "https://doi.org/10.1136/gut.52.12.1728" @default.
• W4230268840 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14633951" @default.
• W4230268840 hasPublicationYear "2003" @default.
• W4230268840 type Work @default.
• W4230268840 citedByCount "70" @default.
• W4230268840 countsByYear W42302688402012 @default.
• W4230268840 countsByYear W42302688402013 @default.
• W4230268840 countsByYear W42302688402014 @default.
• W4230268840 countsByYear W42302688402015 @default.
• W4230268840 countsByYear W42302688402016 @default.
• W4230268840 countsByYear W42302688402017 @default.
• W4230268840 countsByYear W42302688402019 @default.
• W4230268840 countsByYear W42302688402020 @default.
• W4230268840 countsByYear W42302688402021 @default.
• W4230268840 countsByYear W42302688402022 @default.
• W4230268840 crossrefType "journal-article" @default.
• W4230268840 hasAuthorship W4230268840A5050626665 @default.
• W4230268840 hasBestOaLocation W42302688401 @default.
• W4230268840 hasConcept C126322002 @default.
• W4230268840 hasConcept C141071460 @default.
• W4230268840 hasConcept C142724271 @default.
• W4230268840 hasConcept C197934379 @default.
• W4230268840 hasConcept C204787440 @default.
• W4230268840 hasConcept C27081682 @default.
• W4230268840 hasConcept C2776760755 @default.
• W4230268840 hasConcept C2779134260 @default.
• W4230268840 hasConcept C2780479503 @default.
• W4230268840 hasConcept C71924100 @default.
• W4230268840 hasConcept C90924648 @default.
• W4230268840 hasConceptScore W4230268840C126322002 @default.
• W4230268840 hasConceptScore W4230268840C141071460 @default.
• W4230268840 hasConceptScore W4230268840C142724271 @default.
• W4230268840 hasConceptScore W4230268840C197934379 @default.
• W4230268840 hasConceptScore W4230268840C204787440 @default.
• W4230268840 hasConceptScore W4230268840C27081682 @default.
• W4230268840 hasConceptScore W4230268840C2776760755 @default.
• W4230268840 hasConceptScore W4230268840C2779134260 @default.
• W4230268840 hasConceptScore W4230268840C2780479503 @default.
• W4230268840 hasConceptScore W4230268840C71924100 @default.
• W4230268840 hasConceptScore W4230268840C90924648 @default.
• W4230268840 hasIssue "12" @default.
• W4230268840 hasLocation W42302688401 @default.
• W4230268840 hasLocation W42302688402 @default.
• W4230268840 hasLocation W42302688403 @default.
• W4230268840 hasLocation W42302688404 @default.
• W4230268840 hasLocation W42302688405 @default.
• W4230268840 hasOpenAccess W4230268840 @default.
• W4230268840 hasPrimaryLocation W42302688401 @default.
• W4230268840 hasRelatedWork W2012375240 @default.
• W4230268840 hasRelatedWork W2017131874 @default.
• W4230268840 hasRelatedWork W2019704003 @default.
• W4230268840 hasRelatedWork W2047212658 @default.
• W4230268840 hasRelatedWork W2062109784 @default.
• W4230268840 hasRelatedWork W2153190211 @default.
• W4230268840 hasRelatedWork W2405823598 @default.
• W4230268840 hasRelatedWork W2464962541 @default.
• W4230268840 hasRelatedWork W2475104063 @default.
• W4230268840 hasRelatedWork W73433536 @default.
• W4230268840 hasVolume "52" @default.
• W4230268840 isParatext "false" @default.
• W4230268840 isRetracted "false" @default.
• W4230268840 workType "article" @default.