Matches in SemOpenAlex for { <https://semopenalex.org/work/W4230379576> ?p ?o ?g. }
- W4230379576 endingPage "261" @default.
- W4230379576 startingPage "249" @default.
- W4230379576 abstract "Histone methylation plays important roles in chromatin structure, transcription, and epigenetic state of the cell. Tremendous discoveries recently demonstrated that methylation mark is not static but is dynamically regulated by both histone methyltransferases and the histone demethylases. Two families of histone demethylases have been identified to remove methyl groups from lysine side chain through different reaction mechanisms in presence of distinct cofactors. Amine oxidase LSD1 family requires flavin adenine dinucleotide (FAD) whereas dioxygenase Jmjc domain-containing proteins family relies on Fe(II) and alpha-ketoglutarate. Identification of these enzymes opened a new era in understanding how chromatin dynamic is regulated and further understanding the regulation of these enzymes will provide significant insights into fundamental mechanisms of many biological processes and human diseases. This chapter describes different assay conditions and detection methods for different family of histone demethylases. We also summarize step-by-step protocols for purification and preparation of various histone substrates for histone demethylase assays." @default.
- W4230379576 created "2022-05-11" @default.
- W4230379576 creator A5002338395 @default.
- W4230379576 creator A5074972373 @default.
- W4230379576 date "2009-01-01" @default.
- W4230379576 modified "2023-09-30" @default.
- W4230379576 title "In Vitro Histone Demethylase Assays" @default.
- W4230379576 cites W140736740 @default.
- W4230379576 cites W1604254096 @default.
- W4230379576 cites W182747073 @default.
- W4230379576 cites W1972021276 @default.
- W4230379576 cites W1980999513 @default.
- W4230379576 cites W1981452104 @default.
- W4230379576 cites W1985180051 @default.
- W4230379576 cites W1991287841 @default.
- W4230379576 cites W1992868516 @default.
- W4230379576 cites W2002676132 @default.
- W4230379576 cites W2002797826 @default.
- W4230379576 cites W2004127401 @default.
- W4230379576 cites W2008735740 @default.
- W4230379576 cites W2027804136 @default.
- W4230379576 cites W2042765650 @default.
- W4230379576 cites W2044551569 @default.
- W4230379576 cites W2054643318 @default.
- W4230379576 cites W2059059097 @default.
- W4230379576 cites W2059255388 @default.
- W4230379576 cites W2063756611 @default.
- W4230379576 cites W2063982921 @default.
- W4230379576 cites W2067523496 @default.
- W4230379576 cites W2068157186 @default.
- W4230379576 cites W2075907707 @default.
- W4230379576 cites W2077981176 @default.
- W4230379576 cites W2092711959 @default.
- W4230379576 cites W2096083625 @default.
- W4230379576 cites W2099067892 @default.
- W4230379576 cites W2132987256 @default.
- W4230379576 cites W2133148543 @default.
- W4230379576 cites W2139008292 @default.
- W4230379576 cites W2139610636 @default.
- W4230379576 cites W2171210849 @default.
- W4230379576 cites W4212766227 @default.
- W4230379576 doi "https://doi.org/10.1007/978-1-59745-190-1_17" @default.
- W4230379576 hasPublicationYear "2009" @default.
- W4230379576 type Work @default.
- W4230379576 citedByCount "5" @default.
- W4230379576 countsByYear W42303795762012 @default.
- W4230379576 countsByYear W42303795762014 @default.
- W4230379576 countsByYear W42303795762017 @default.
- W4230379576 crossrefType "book-chapter" @default.
- W4230379576 hasAuthorship W4230379576A5002338395 @default.
- W4230379576 hasAuthorship W4230379576A5074972373 @default.
- W4230379576 hasConcept C10058791 @default.
- W4230379576 hasConcept C104317684 @default.
- W4230379576 hasConcept C121912465 @default.
- W4230379576 hasConcept C150194340 @default.
- W4230379576 hasConcept C150425827 @default.
- W4230379576 hasConcept C190727270 @default.
- W4230379576 hasConcept C22709980 @default.
- W4230379576 hasConcept C2781364455 @default.
- W4230379576 hasConcept C41091548 @default.
- W4230379576 hasConcept C552990157 @default.
- W4230379576 hasConcept C55493867 @default.
- W4230379576 hasConcept C56428682 @default.
- W4230379576 hasConcept C64927066 @default.
- W4230379576 hasConcept C83640560 @default.
- W4230379576 hasConcept C84772758 @default.
- W4230379576 hasConcept C86803240 @default.
- W4230379576 hasConceptScore W4230379576C10058791 @default.
- W4230379576 hasConceptScore W4230379576C104317684 @default.
- W4230379576 hasConceptScore W4230379576C121912465 @default.
- W4230379576 hasConceptScore W4230379576C150194340 @default.
- W4230379576 hasConceptScore W4230379576C150425827 @default.
- W4230379576 hasConceptScore W4230379576C190727270 @default.
- W4230379576 hasConceptScore W4230379576C22709980 @default.
- W4230379576 hasConceptScore W4230379576C2781364455 @default.
- W4230379576 hasConceptScore W4230379576C41091548 @default.
- W4230379576 hasConceptScore W4230379576C552990157 @default.
- W4230379576 hasConceptScore W4230379576C55493867 @default.
- W4230379576 hasConceptScore W4230379576C56428682 @default.
- W4230379576 hasConceptScore W4230379576C64927066 @default.
- W4230379576 hasConceptScore W4230379576C83640560 @default.
- W4230379576 hasConceptScore W4230379576C84772758 @default.
- W4230379576 hasConceptScore W4230379576C86803240 @default.
- W4230379576 hasLocation W42303795761 @default.
- W4230379576 hasOpenAccess W4230379576 @default.
- W4230379576 hasPrimaryLocation W42303795761 @default.
- W4230379576 hasRelatedWork W2016018631 @default.
- W4230379576 hasRelatedWork W2033441226 @default.
- W4230379576 hasRelatedWork W2060903701 @default.
- W4230379576 hasRelatedWork W2085180690 @default.
- W4230379576 hasRelatedWork W2108594108 @default.
- W4230379576 hasRelatedWork W2129191426 @default.
- W4230379576 hasRelatedWork W2142998511 @default.
- W4230379576 hasRelatedWork W2159831588 @default.
- W4230379576 hasRelatedWork W2508554480 @default.
- W4230379576 hasRelatedWork W4377020936 @default.
- W4230379576 isParatext "false" @default.
- W4230379576 isRetracted "false" @default.