Matches in SemOpenAlex for { <https://semopenalex.org/work/W4230385802> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4230385802 endingPage "tw262" @default.
- W4230385802 startingPage "tw262" @default.
- W4230385802 abstract "Maillet et al. determined that regulation of secretion of nonamyloidogenic soluble amyloid precursor protein (sAPPα) was mediated by a novel signal transduction pathway involving crosstalk between the Ras and Rho families of small guanosine triphosphatases (GTPases). Activation of the Gs-coupled serotonin (5-HT4) receptor stimulated sAPPα release in Chinese hamster ovary (CHO) cells transfected to express both human 5-HT4 receptors and a human APP and in primary cultures of mouse cortical neurons. [Gs are the family of heterotrimeric guanine nucleotide-binding protein (G protein) α subunits that stimulate adenylyl cyclase.] Pharmacologic analysis indicated that 5-HT4-mediated sAPPα secretion involved cyclic adenosine 3′,5′-monophosphate (cAMP), but was independent of protein kinase A (PKA). Similarly, 5-HT4-mediated activation of the Rho GTPase Rac (assessed by the fraction of GTP-bound Rac to total Rac) through a mechanism that involved cAMP but was independent of PKA. Further pharmacologic analysis, combined with expression of various mutants of Rac, the Ras GTPase Rap1, and Epac1 (cAMP-activated guanine nucleotide exchange factor for Rap1), indicated that cAMP stimulated Epac1, which activated Rap1, which led to activation of Rac and sAPPα secretion. These data thus define a novel cAMP-dependent pathway involved in the regulation of sAPPα secretion.M. Maillet, S. J. Robert, M. Cacquevel, M. Gastineau, D. Vivien, J. Bertoglio, J. L. Zugaza, R. Fischmeister, F. Lezoualc'h, Crosstalk between Rap1 and Rac regulates secretion of sAPPα. Nat. Cell. Biol. 5 633-639 (2003). [Online Journal]" @default.
- W4230385802 created "2022-05-11" @default.
- W4230385802 date "2003-07-08" @default.
- W4230385802 modified "2023-09-27" @default.
- W4230385802 title "Rac and Rap1 Regulate Soluble Amyloid Precursor Protein Secretion" @default.
- W4230385802 doi "https://doi.org/10.1126/scisignal.1902003tw262" @default.
- W4230385802 hasPublicationYear "2003" @default.
- W4230385802 type Work @default.
- W4230385802 citedByCount "0" @default.
- W4230385802 crossrefType "journal-article" @default.
- W4230385802 hasConcept C118716 @default.
- W4230385802 hasConcept C126619667 @default.
- W4230385802 hasConcept C139407321 @default.
- W4230385802 hasConcept C181199279 @default.
- W4230385802 hasConcept C184235292 @default.
- W4230385802 hasConcept C207332259 @default.
- W4230385802 hasConcept C2776179587 @default.
- W4230385802 hasConcept C2777995097 @default.
- W4230385802 hasConcept C2779178603 @default.
- W4230385802 hasConcept C49039625 @default.
- W4230385802 hasConcept C55493867 @default.
- W4230385802 hasConcept C62478195 @default.
- W4230385802 hasConcept C66135807 @default.
- W4230385802 hasConcept C80631254 @default.
- W4230385802 hasConcept C85771745 @default.
- W4230385802 hasConcept C86803240 @default.
- W4230385802 hasConcept C95444343 @default.
- W4230385802 hasConcept C97029542 @default.
- W4230385802 hasConceptScore W4230385802C118716 @default.
- W4230385802 hasConceptScore W4230385802C126619667 @default.
- W4230385802 hasConceptScore W4230385802C139407321 @default.
- W4230385802 hasConceptScore W4230385802C181199279 @default.
- W4230385802 hasConceptScore W4230385802C184235292 @default.
- W4230385802 hasConceptScore W4230385802C207332259 @default.
- W4230385802 hasConceptScore W4230385802C2776179587 @default.
- W4230385802 hasConceptScore W4230385802C2777995097 @default.
- W4230385802 hasConceptScore W4230385802C2779178603 @default.
- W4230385802 hasConceptScore W4230385802C49039625 @default.
- W4230385802 hasConceptScore W4230385802C55493867 @default.
- W4230385802 hasConceptScore W4230385802C62478195 @default.
- W4230385802 hasConceptScore W4230385802C66135807 @default.
- W4230385802 hasConceptScore W4230385802C80631254 @default.
- W4230385802 hasConceptScore W4230385802C85771745 @default.
- W4230385802 hasConceptScore W4230385802C86803240 @default.
- W4230385802 hasConceptScore W4230385802C95444343 @default.
- W4230385802 hasConceptScore W4230385802C97029542 @default.
- W4230385802 hasIssue "190" @default.
- W4230385802 hasLocation W42303858021 @default.
- W4230385802 hasOpenAccess W4230385802 @default.
- W4230385802 hasPrimaryLocation W42303858021 @default.
- W4230385802 hasRelatedWork W135990741 @default.
- W4230385802 hasRelatedWork W1708235231 @default.
- W4230385802 hasRelatedWork W1986914092 @default.
- W4230385802 hasRelatedWork W1987549967 @default.
- W4230385802 hasRelatedWork W2034381478 @default.
- W4230385802 hasRelatedWork W2095013577 @default.
- W4230385802 hasRelatedWork W2972207994 @default.
- W4230385802 hasRelatedWork W4231116471 @default.
- W4230385802 hasRelatedWork W4231175437 @default.
- W4230385802 hasRelatedWork W4242288745 @default.
- W4230385802 hasVolume "2003" @default.
- W4230385802 isParatext "false" @default.
- W4230385802 isRetracted "false" @default.
- W4230385802 workType "article" @default.