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- W4230391025 abstract "Studies with mouse leukemia L1210 cells revealed that selective lysosomal photodamage caused by any of three photosensitizing agents was followed by a gradual loss of the mitochondrial membrane potential (ΔΨm), release of cytochrome c into the cytosol, increased DEVDase activity (a measure of levels of caspase-3) and a limited apoptotic response. Similar effects were observed in the murine hepatoma 1c1c7 cell line. Immunofluorescence techniques employing 1c1c7 cells demonstrated the immediate release of the lysosomal enzyme cathepsin B following lysosomal photodamage. These studies suggest that the cytotoxic effects of lysosomal photodamage are initiated by released lysosomal proteases that either directly and/or indirectly activate caspases as a consequence of the induction of mitochondrial damage." @default.
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- W4230391025 date "2007-05-01" @default.
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- W4230391025 title "Determinants of the Apoptotic Response to Lysosomal Photodamage" @default.
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- W4230391025 doi "https://doi.org/10.1562/0031-8655(2000)0710196dotart2.0.co2" @default.
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