Matches in SemOpenAlex for { <https://semopenalex.org/work/W4230393493> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W4230393493 abstract "Ultrasound (US)-targeted microbubble (MB) destruction (UTMD) can significantly enhance gene delivery in mouse livers when pDNA/MBs were injected into the portal vein (PV) with simultaneous US exposure using a focused transducer. However, this transducer was ineffective in enhancing gene transfer into rats. A 13-mm diameter unfocused transducer was designed and the delivery route of pDNA/MBs was modified into a specific liver lobe, resulting in >100-fold increase in luciferase expression in rats. To facilitate the translation into human applications, many technical issues were explored in large animal models. We applied 1.1 MHz US to targeted canine and swine liver lobes with simultaneous injection of pDNA/MBs into a PV segmental branch and occlusion of the inferior vena cava. For more effective treatment of large tissue volumes, a 52-mm apodized, dual element unfocused transducer was specifically constructed to reduce the near field transaxial pressure variations, producing a uniform field of US exposure. Together with a 15 kW-capacity US amplifier, a 692-fold and 1800-fold increases of gene expression in canines and swines were achieved at 2.7-MPa, respectively. Transaminase levels and histology analysis indicated minimal tissue damage. These results demonstrated that UTMD is highly promising for safe and efficient gene delivery into the liver." @default.
- W4230393493 created "2022-05-11" @default.
- W4230393493 creator A5018744262 @default.
- W4230393493 creator A5022447244 @default.
- W4230393493 creator A5022960930 @default.
- W4230393493 creator A5030933976 @default.
- W4230393493 creator A5036575411 @default.
- W4230393493 creator A5046941636 @default.
- W4230393493 creator A5047984172 @default.
- W4230393493 creator A5049863484 @default.
- W4230393493 creator A5058742287 @default.
- W4230393493 creator A5065358447 @default.
- W4230393493 creator A5072086449 @default.
- W4230393493 creator A5072576696 @default.
- W4230393493 creator A5085787488 @default.
- W4230393493 date "2013-01-01" @default.
- W4230393493 modified "2023-10-14" @default.
- W4230393493 title "Effective ultrasound-targeted microbubble destruction (UTMD)-mediated gene transfer into the livers of small and large animals" @default.
- W4230393493 doi "https://doi.org/10.1121/1.4801418" @default.
- W4230393493 hasPublicationYear "2013" @default.
- W4230393493 type Work @default.
- W4230393493 citedByCount "0" @default.
- W4230393493 crossrefType "proceedings-article" @default.
- W4230393493 hasAuthorship W4230393493A5018744262 @default.
- W4230393493 hasAuthorship W4230393493A5022447244 @default.
- W4230393493 hasAuthorship W4230393493A5022960930 @default.
- W4230393493 hasAuthorship W4230393493A5030933976 @default.
- W4230393493 hasAuthorship W4230393493A5036575411 @default.
- W4230393493 hasAuthorship W4230393493A5046941636 @default.
- W4230393493 hasAuthorship W4230393493A5047984172 @default.
- W4230393493 hasAuthorship W4230393493A5049863484 @default.
- W4230393493 hasAuthorship W4230393493A5058742287 @default.
- W4230393493 hasAuthorship W4230393493A5065358447 @default.
- W4230393493 hasAuthorship W4230393493A5072086449 @default.
- W4230393493 hasAuthorship W4230393493A5072576696 @default.
- W4230393493 hasAuthorship W4230393493A5085787488 @default.
- W4230393493 hasBestOaLocation W42303934931 @default.
- W4230393493 hasConcept C121332964 @default.
- W4230393493 hasConcept C126322002 @default.
- W4230393493 hasConcept C126838900 @default.
- W4230393493 hasConcept C136229726 @default.
- W4230393493 hasConcept C142724271 @default.
- W4230393493 hasConcept C143753070 @default.
- W4230393493 hasConcept C192562407 @default.
- W4230393493 hasConcept C24890656 @default.
- W4230393493 hasConcept C2909484270 @default.
- W4230393493 hasConcept C2910216633 @default.
- W4230393493 hasConcept C56318395 @default.
- W4230393493 hasConcept C71924100 @default.
- W4230393493 hasConceptScore W4230393493C121332964 @default.
- W4230393493 hasConceptScore W4230393493C126322002 @default.
- W4230393493 hasConceptScore W4230393493C126838900 @default.
- W4230393493 hasConceptScore W4230393493C136229726 @default.
- W4230393493 hasConceptScore W4230393493C142724271 @default.
- W4230393493 hasConceptScore W4230393493C143753070 @default.
- W4230393493 hasConceptScore W4230393493C192562407 @default.
- W4230393493 hasConceptScore W4230393493C24890656 @default.
- W4230393493 hasConceptScore W4230393493C2909484270 @default.
- W4230393493 hasConceptScore W4230393493C2910216633 @default.
- W4230393493 hasConceptScore W4230393493C56318395 @default.
- W4230393493 hasConceptScore W4230393493C71924100 @default.
- W4230393493 hasLocation W42303934931 @default.
- W4230393493 hasOpenAccess W4230393493 @default.
- W4230393493 hasPrimaryLocation W42303934931 @default.
- W4230393493 hasRelatedWork W1998665895 @default.
- W4230393493 hasRelatedWork W2022740803 @default.
- W4230393493 hasRelatedWork W2024819079 @default.
- W4230393493 hasRelatedWork W2109490822 @default.
- W4230393493 hasRelatedWork W2120134923 @default.
- W4230393493 hasRelatedWork W2155299022 @default.
- W4230393493 hasRelatedWork W2234342825 @default.
- W4230393493 hasRelatedWork W2901751297 @default.
- W4230393493 hasRelatedWork W4229027721 @default.
- W4230393493 hasRelatedWork W4307091047 @default.
- W4230393493 isParatext "false" @default.
- W4230393493 isRetracted "false" @default.
- W4230393493 workType "article" @default.