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- W4230402393 abstract "White matter hyperintensity (WMH) penumbra is the normal appearing white matter (NAWM) surrounding WMH that demonstrates decreased structural integrity and perfusion, and is vulnerable to becoming injured white matter. Previous longitudinal work has shown that baseline cerebral blood flow (CBF), DTI-FA, and FLAIR intensity can predict WMH expansion over time. However, none of the previous studies identified which signal can best predict the growth of WMH and none performed voxel-wise analysis. The aim of this study was to identify the sensitivity of CBF, DTI and FLAIR signals in predicting WMH development. Fifty-two cognitively intact (CDR = 0) elderly volunteers (mean age 83.5 years old) underwent two scan visits with 3T MRI FLAIR, MPRAGE, PASL and DTI. The mean interscan interval was 16 months. For each individual dataset, baseline and follow-up WMH were aligned and subtracted from each other, creating a binary map containing 0s and 1s for persistent NAWM and new WMH voxels, respectively. We focused on the 5 mm area surrounding WMH where there was significant growth of WMHs. Baseline CBF map. DTI-FA, DTI-MD and FLAIR images were then registered to the binary map. Correlation analysis was performed between the binary map and CBF map, DTI and FLAIR images, individually. The predictive order was determined by comparing the group mean R2 using paired t-test. Increased FLAIR intensity had the strongest correlation with new WMH voxels, followed by increased DTI-MD, decreased DTI-FA and decreased CBF for both periventricular (PV) and deep WMH penumbras (p<0.001). Mean R2, ordered from greatest to smallest associations, are 0.072, 0.014, 0.011, and 0.005 for PV WMHs, and are 0.025, 0.014, 0.004, and 0.001 for deep WMHs. Within the immediate WMH environment, baseline indicators of microstructural WM damage are more predictive of future WMH expansion than CBF. For future studies, investigating the contribution of CBF to future microstructural WM degeneration is needed." @default.
- W4230402393 created "2022-05-11" @default.
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- W4230402393 date "2016-07-01" @default.
- W4230402393 modified "2023-09-27" @default.
- W4230402393 title "O2-03-04: Baseline Normal Appearing White Matter Structural Integrity and Cerebral Blood Flow Can Predict White Matter Hyperintensity Expansion Over Time: a Voxel-Wise Analysis" @default.
- W4230402393 doi "https://doi.org/10.1016/j.jalz.2016.06.408" @default.
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