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- W42304417 abstract "Publisher Summary This chapter discusses the role of catecholamines (CA) in induction of adrenal tyrosine hydroxylase. CA in sympathetic nerves and in the adrenal medulla is stored in dense core vesicles from which they are continuously being released. Under varying physiological conditions, the CA content remains at a steady-state level characteristic of each organ. To a considerable extent, this is because of continuous synthesis of CA which keeps pace with the rate of release, and consequently there is only slight or no reduction in CA content of the tissue. Four enzymes are involved in the biosynthesis of epinephrine from tyrosine: tyrosine hydroxylase (TH), dopa decarboxylase, dopamine β-oxidase and phenylethanolamine- N -methyl transferase (PNMT). NE and other catechols have been shown to inhibit the TH, a rate limiting enzyme in the biosynthesis of CA. This inhibition is not competitive with the substrate, but with tetrahydropteridine co-factor. Because the concentration of co-factor within the cytoplasm of the adrenergic neuron is less than 1 mM, it is possible that a very small amount of CA is able to antagonize its actions and thus may exert considerable influence on the enzymatic activity of TH." @default.
- W42304417 created "2016-06-24" @default.
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- W42304417 date "1973-01-01" @default.
- W42304417 modified "2023-10-16" @default.
- W42304417 title "ROLE OF CATECHOLAMINES IN INDUCTION OF ADRENAL TYROSINE HYDROXYLASE" @default.
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- W42304417 doi "https://doi.org/10.1016/b978-0-08-017922-3.50035-6" @default.
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