Matches in SemOpenAlex for { <https://semopenalex.org/work/W4230447785> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W4230447785 endingPage "25" @default.
- W4230447785 startingPage "18" @default.
- W4230447785 abstract "Acta Physiologica ScandinavicaVolume 75, Issue s319 p. 18-25 HAEMODYNAMIC EFFECTS OF TISSUE THROMBOPLASTIN AND THROMBIN IN DOGS First published: April 1968 https://doi.org/10.1111/j.1748-1716.1968.tb04420.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Summary Tissue thromboplastin and thrombin were infused into a femoral artery or into a central vein of dogs, and the femoral arterial blood flow and the aortic blood pressure were registered. Intra-arterial infusion of dialyzed homologous tissue thromboplastin or purified human tissue thromboplastin had no local flow-increasing effects. Larger amounts produced hypotension, which might have been due partly to thrombin formation. Intra-arterial infusion of small amounts of thrombin resulted in a local flow increase, whereas larger amounts produced an initial increase, rapidly followed by a decrease. The increase in blood flow seemed to be due to vasodilatation, whereas the decrease was probably due to coagulation. Thrombin given intravenously to defibrinogenated animals caused a fall in the aortic blood pressure. Fibrinopeptides and clot supernatants from fibrinogen had no vasodilating activity. The vasodilating activity of thrombin was the same in normal as in defibrinogenated animals. It is thus improbable that products of the thrombin-fibrinogen reaction are mediators of the thrombin-induced vasodilatation. Large intravenous infusions of kallikrein made dogs resistant to intra-arterially infused kallikrein and bradykinin, but not to thrombin. Large intravenous infusions of thrombin, on the other hand, made the dogs resistant to intra-arterially infused thrombin, but not to kallikrein and bradykinin. These results, and the finding that no vasoactivity was generated during incubation of bradykininogen with thrombin in vitro, indicate that the vasodilating activity of thrombin is not mediated by plasma kinins. No vasoactivity was found after incubation of platelet-poor plasma with thrombin in vitro. However, incubates of whole blood or platelet-rich cell suspension with thrombin showed vasoactivity. The presence of blood cells thus seems to be of importance for the vasoactivity of thrombin. Volume75, Issues319April 1968Pages 18-25 RelatedInformation" @default.
- W4230447785 created "2022-05-11" @default.
- W4230447785 date "1968-04-01" @default.
- W4230447785 modified "2023-09-25" @default.
- W4230447785 title "HAEMODYNAMIC EFFECTS OF TISSUE THROMBOPLASTIN AND THROMBIN IN DOGS" @default.
- W4230447785 doi "https://doi.org/10.1111/j.1748-1716.1968.tb04420.x" @default.
- W4230447785 hasPublicationYear "1968" @default.
- W4230447785 type Work @default.
- W4230447785 citedByCount "0" @default.
- W4230447785 crossrefType "journal-article" @default.
- W4230447785 hasConcept C120770815 @default.
- W4230447785 hasConcept C126322002 @default.
- W4230447785 hasConcept C144594695 @default.
- W4230447785 hasConcept C158846371 @default.
- W4230447785 hasConcept C164705383 @default.
- W4230447785 hasConcept C178853913 @default.
- W4230447785 hasConcept C186738567 @default.
- W4230447785 hasConcept C2777292125 @default.
- W4230447785 hasConcept C2778261982 @default.
- W4230447785 hasConcept C2778382381 @default.
- W4230447785 hasConcept C2778854125 @default.
- W4230447785 hasConcept C42219234 @default.
- W4230447785 hasConcept C71924100 @default.
- W4230447785 hasConcept C84393581 @default.
- W4230447785 hasConcept C89560881 @default.
- W4230447785 hasConceptScore W4230447785C120770815 @default.
- W4230447785 hasConceptScore W4230447785C126322002 @default.
- W4230447785 hasConceptScore W4230447785C144594695 @default.
- W4230447785 hasConceptScore W4230447785C158846371 @default.
- W4230447785 hasConceptScore W4230447785C164705383 @default.
- W4230447785 hasConceptScore W4230447785C178853913 @default.
- W4230447785 hasConceptScore W4230447785C186738567 @default.
- W4230447785 hasConceptScore W4230447785C2777292125 @default.
- W4230447785 hasConceptScore W4230447785C2778261982 @default.
- W4230447785 hasConceptScore W4230447785C2778382381 @default.
- W4230447785 hasConceptScore W4230447785C2778854125 @default.
- W4230447785 hasConceptScore W4230447785C42219234 @default.
- W4230447785 hasConceptScore W4230447785C71924100 @default.
- W4230447785 hasConceptScore W4230447785C84393581 @default.
- W4230447785 hasConceptScore W4230447785C89560881 @default.
- W4230447785 hasLocation W42304477851 @default.
- W4230447785 hasOpenAccess W4230447785 @default.
- W4230447785 hasPrimaryLocation W42304477851 @default.
- W4230447785 hasRelatedWork W1965189182 @default.
- W4230447785 hasRelatedWork W2023594284 @default.
- W4230447785 hasRelatedWork W2034244390 @default.
- W4230447785 hasRelatedWork W2043782442 @default.
- W4230447785 hasRelatedWork W2167893561 @default.
- W4230447785 hasRelatedWork W2330625864 @default.
- W4230447785 hasRelatedWork W2366308376 @default.
- W4230447785 hasRelatedWork W2770435532 @default.
- W4230447785 hasRelatedWork W3023056416 @default.
- W4230447785 hasRelatedWork W4200427433 @default.
- W4230447785 hasVolume "75" @default.
- W4230447785 isParatext "false" @default.
- W4230447785 isRetracted "false" @default.
- W4230447785 workType "article" @default.