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- W4230487862 abstract "<p>Telomerase is a ribonuceloprotein complex responsible for maintaining telomeres and protecting chromosomal integrity. The human telomerase reverse transcriptase (hTERT) is expressed in ~90% of cancer cells where it confers the capacity for limitless proliferation. Along with its established role in telomere lengthening, telomerase also serves non-canonical extra-telomeric roles in oncogenic signaling, resistance to apoptosis, and enhanced DNA damage response. Here, we report a new class of natural product-inspired covalent inhibitors of telomerase that target the catalytic active site. We developed rationally designed probe compounds that modulate both the telomeric and extra-telomeric activities of telomerase and present new opportunities to investigate the diverse functions of this unique molecular machine.</p>" @default.
- W4230487862 created "2022-05-11" @default.
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- W4230487862 date "2019-07-23" @default.
- W4230487862 modified "2023-09-30" @default.
- W4230487862 title "Targeted Covalent Inhibition of Telomerase" @default.
- W4230487862 doi "https://doi.org/10.26434/chemrxiv.8977457.v1" @default.
- W4230487862 hasPublicationYear "2019" @default.
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