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- W4230492776 endingPage "189" @default.
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- W4230492776 abstract "Three new Ru(II) complexes, [Ru(dmb)2(ipad)](ClO4)2 (dmb = 4,4′-dimethyl-2,2′-bipyridine, ipad = 2-(anthracene-9,10-dione-2-yl) imidazo[4,5-f][1,10]phenanthroline, 1), [Ru(dmp)2(ipad)](ClO4)2 (dmp = 2,9-dimethyl-1,10-phenanthroline, 2), and [Ru(dip)2(ipad)](ClO4)2 (dip = 4,7-diphenyl-1,10-phenanthroline, 3), have been synthesized and characterized. The three Ru(II) complexes intercalate with the base pairs of DNA. The in vitro antiproliferative activities and apoptosis-inducing characteristics of these complexes were investigated. The complexes exhibited cytotoxicity against various human cancer cell lines. BEL-7402 cells displayed the highest sensitivity to 1, accounted for by the greatest cellular uptake. Complex 1 was shown to accumulate preferentially in the nuclei of BEL-7402 cells and cause DNA damage and induce apoptosis, which involved cell cycle arrest and reactive oxygen species generation." @default.
- W4230492776 created "2022-05-11" @default.
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- W4230492776 date "2016-01-17" @default.
- W4230492776 modified "2023-09-26" @default.
- W4230492776 title "Synthesis, characterization, and antitumor properties of ruthenium(II) anthraquinone complexes" @default.
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- W4230492776 doi "https://doi.org/10.1080/00958972.2015.1120291" @default.
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