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- W4230503544 abstract "The effect of TEI-6363 (5-[E-4-N, N-dimethylaminophenylmethylene]-4-hydroxy-2-[1-methyl imidazole-2-ilthio]-4-[4-phenylbutyl]-2-cyclopentenone), a chemically synthesized prostaglandin A1 derivative, on cell proliferation and osteoblastic differentiation was investigated concurrently. ROS17/2.8 cells (a rat osteosarcoma-derived cell line) were treated with TEI-6363 at two concentrations, 10-7 and 10-6 M, and viable cells were counted to assess cytotoxic effects and determine the growth curve. After 96 h of treatment, there was no evidence of any effect of TEI-6363 on cell viability at either concentration. However, a clear inhibitory effect on cell proliferation was observed after treatment with 10-6 M TEI-6363 for 24 h or longer. A pulse-treatment experiment showed that TEI-6363 induced the inhibition of proliferating ROS17/2.8 cells 24 h after addition. The inhibition of proliferation was associated with Gl-arrest demonstrated by flow cytometric analysis, and incorporation of [3H]thymidine by ROS17/2.8 cells was decreased. Osteoblastic differentiation (assessed on the basis of increased alkaline phosphatase activity and collagen synthesis) was induced by TEI-6363 treatment at 10-6M following Gl-arrest and inhibition of cell proliferation. These results suggest that TEI-6363 arrested the cell cycle of ROS 17/2.8 cells at the Gl phase and induced osteoblastic differentiation. These results did not appear to be dependent on a marked cytotoxic effect." @default.
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- W4230503544 date "2000-01-01" @default.
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- W4230503544 title "Effect of the Novel Prostaglandin A1 Derivative TEI-6363 on ROS17/2.8 Cell Differentiation In Vitro" @default.
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- W4230503544 doi "https://doi.org/10.1016/s0021-5198(19)30591-8" @default.
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