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- W4230607456 abstract "Abstract Background Recently, abundant numbers of studies have revealed many functions of circular RNAs in multiple diseases, however, the role of circular RNA in the rupture of human intracranial aneurysm is still unknown. This study aims to explore the potential functions of circular RNA in the rupture of human intracranial aneurysms. Results The differentially expressed circular RNAs between un-ruptured intracranial aneurysms (n = 5) and ruptured intracranial aneurysms (n = 5) were analyzed with the Arraystar human circRNAs microarray and total of 13175 circular RNAs were detected. Among them 63 circular RNAs upregulated and 54 circular RNAs downregulated significantly in ruptured intracranial aneurysms compared with un-ruptured intracranial aneurysms (p < 0.05, Fold Change > 1.5). 5 upregulated circular RNAs were selected for further study (hsa_circ_0001947, hsa_circ_0043001, hsa_circ_0064557, hsa_circ_0058514, hsa_circ_0005505). The results of qPCR showed only hsa_circ_0005505 significantly upregulated (P < 0.05). The expression of hsa_circ_0005505 was higher in ruptured intracranial aneurysm tissues. And our in vitro data showed that hsa_circRNA_005505 promotes the proliferation the migration and apoptosis of vascular smooth muscle cell. Conclusions This study revealed an important role of hsa_circ_0005505 in the proliferation, migration and apoptosis of vascular smooth muscle cell, and indicated that hsa_circ_0005505 may associated with the pathological process of intracranial aneurysms." @default.
- W4230607456 created "2022-05-11" @default.
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- W4230607456 date "2021-02-23" @default.
- W4230607456 modified "2023-09-23" @default.
- W4230607456 title "The potential role of hsa_circ_0005505 in the rupture of human intracranial aneurysm" @default.
- W4230607456 doi "https://doi.org/10.21203/rs.3.rs-210322/v1" @default.
- W4230607456 hasPublicationYear "2021" @default.
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