FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4230607530> ?p ?o ?g. }

• W4230607530 endingPage "2549" @default.
• W4230607530 startingPage "2545" @default.
• W4230607530 abstract "Poly(ADP-ribose)polymerase-1 (PARP1) is a BRCT-containing enzyme (BRCT=BRCA1 C-terminus) mainly involved in DNA repair and damage response and a validated target for cancer treatment. Small-molecule inhibitors that target the PARP1 catalytic domain have been actively pursued as anticancer drugs, but are potentially problematic owing to a lack of selectivity. Compounds that are capable of disrupting protein–protein interactions of PARP1 provide an alternative by inhibiting its activities with improved selectivity profiles. Herein, by establishing a high-throughput microplate-based assay suitable for screening potential PPI inhibitors of the PARP1 BRCT domain, we have discovered that (±)-gossypol, a natural product with a number of known biological activities, possesses novel PARP1 inhibitory activity both in vitro and in cancer cells and presumably acts through disruption of protein–protein interactions. As the first known cell-permeable small-molecule PPI inhibitor of PAPR1, we further established that (−)-gossypol was likely the causative agent of PARP1 inhibition by promoting the formation of a 1:2 compound/PARP1 complex by reversible formation of a covalent imine linkage." @default.
• W4230607530 created "2022-05-11" @default.
• W4230607530 creator A5007605434 @default.
• W4230607530 creator A5019752084 @default.
• W4230607530 creator A5021926450 @default.
• W4230607530 creator A5044619252 @default.
• W4230607530 creator A5063480657 @default.
• W4230607530 creator A5065651921 @default.
• W4230607530 creator A5068648018 @default.
• W4230607530 date "2015-01-07" @default.
• W4230607530 modified "2023-10-06" @default.
• W4230607530 title "A Small-Molecule Protein-Protein Interaction Inhibitor of PARP1 That Targets Its BRCT Domain" @default.
• W4230607530 cites W1965006127 @default.
• W4230607530 cites W1967439927 @default.
• W4230607530 cites W1993251792 @default.
• W4230607530 cites W1993582972 @default.
• W4230607530 cites W1999460643 @default.
• W4230607530 cites W2001762032 @default.
• W4230607530 cites W2009339798 @default.
• W4230607530 cites W2014035904 @default.
• W4230607530 cites W2042067610 @default.
• W4230607530 cites W2043068232 @default.
• W4230607530 cites W2056283033 @default.
• W4230607530 cites W2056539144 @default.
• W4230607530 cites W2058058143 @default.
• W4230607530 cites W2065107886 @default.
• W4230607530 cites W2073660843 @default.
• W4230607530 cites W2076619368 @default.
• W4230607530 cites W2085215116 @default.
• W4230607530 cites W2088689845 @default.
• W4230607530 cites W2093662743 @default.
• W4230607530 cites W2097857601 @default.
• W4230607530 cites W2109409755 @default.
• W4230607530 cites W2116398119 @default.
• W4230607530 cites W2135832572 @default.
• W4230607530 cites W2147154862 @default.
• W4230607530 cites W2151571025 @default.
• W4230607530 cites W2167398093 @default.
• W4230607530 cites W2171972386 @default.
• W4230607530 cites W4235755155 @default.
• W4230607530 cites W4237795980 @default.
• W4230607530 cites W4249106612 @default.
• W4230607530 cites W4254683620 @default.
• W4230607530 doi "https://doi.org/10.1002/ange.201410678" @default.
• W4230607530 hasPublicationYear "2015" @default.
• W4230607530 type Work @default.
• W4230607530 citedByCount "11" @default.
• W4230607530 countsByYear W42306075302015 @default.
• W4230607530 countsByYear W42306075302016 @default.
• W4230607530 countsByYear W42306075302017 @default.
• W4230607530 countsByYear W42306075302018 @default.
• W4230607530 countsByYear W42306075302020 @default.
• W4230607530 countsByYear W42306075302021 @default.
• W4230607530 crossrefType "journal-article" @default.
• W4230607530 hasAuthorship W4230607530A5007605434 @default.
• W4230607530 hasAuthorship W4230607530A5019752084 @default.
• W4230607530 hasAuthorship W4230607530A5021926450 @default.
• W4230607530 hasAuthorship W4230607530A5044619252 @default.
• W4230607530 hasAuthorship W4230607530A5063480657 @default.
• W4230607530 hasAuthorship W4230607530A5065651921 @default.
• W4230607530 hasAuthorship W4230607530A5068648018 @default.
• W4230607530 hasConcept C104317684 @default.
• W4230607530 hasConcept C11804247 @default.
• W4230607530 hasConcept C161624437 @default.
• W4230607530 hasConcept C181199279 @default.
• W4230607530 hasConcept C182979987 @default.
• W4230607530 hasConcept C185592680 @default.
• W4230607530 hasConcept C2776653637 @default.
• W4230607530 hasConcept C2778480876 @default.
• W4230607530 hasConcept C2780430158 @default.
• W4230607530 hasConcept C55493867 @default.
• W4230607530 hasConcept C82381507 @default.
• W4230607530 hasConcept C86803240 @default.
• W4230607530 hasConcept C95444343 @default.
• W4230607530 hasConceptScore W4230607530C104317684 @default.
• W4230607530 hasConceptScore W4230607530C11804247 @default.
• W4230607530 hasConceptScore W4230607530C161624437 @default.
• W4230607530 hasConceptScore W4230607530C181199279 @default.
• W4230607530 hasConceptScore W4230607530C182979987 @default.
• W4230607530 hasConceptScore W4230607530C185592680 @default.
• W4230607530 hasConceptScore W4230607530C2776653637 @default.
• W4230607530 hasConceptScore W4230607530C2778480876 @default.
• W4230607530 hasConceptScore W4230607530C2780430158 @default.
• W4230607530 hasConceptScore W4230607530C55493867 @default.
• W4230607530 hasConceptScore W4230607530C82381507 @default.
• W4230607530 hasConceptScore W4230607530C86803240 @default.
• W4230607530 hasConceptScore W4230607530C95444343 @default.
• W4230607530 hasIssue "8" @default.
• W4230607530 hasLocation W42306075301 @default.
• W4230607530 hasOpenAccess W4230607530 @default.
• W4230607530 hasPrimaryLocation W42306075301 @default.
• W4230607530 hasRelatedWork W1967366712 @default.
• W4230607530 hasRelatedWork W2066712271 @default.
• W4230607530 hasRelatedWork W2082618949 @default.
• W4230607530 hasRelatedWork W2152603778 @default.
• W4230607530 hasRelatedWork W2604684522 @default.
• W4230607530 hasRelatedWork W3181862256 @default.
• W4230607530 hasRelatedWork W4206015794 @default.

• next