FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4230625089> ?p ?o ?g. }

• W4230625089 endingPage "fvi" @default.
• W4230625089 startingPage "fvi" @default.
• W4230625089 abstract "“Highlights” calls attention to exciting advances in developmental biology that have recently been reported in Developmental Dynamics. Development is a broad field encompassing many important areas. To reflect this fact, the section spotlights significant discoveries that occur across the entire spectrum of developmental events and problems: from new experimental approaches, to novel interpretations of results, to noteworthy findings utilizing different developmental organisms. Finding a niche (Dev Dyn 237:592–601) Some need to be in just the right environment, perhaps in the company of cocktails and good friends, before they can be themselves. Blentic and colleagues set out to find just what makes ectomesenchymal neural crest, precursors to bone, cartilage, connective tissue, and dentine, who they are. They find that upon entry to phyaryngeal arches, ectomesenchymal creast cease to transcribe Sox10, as assayed by reorter expression. Unlike other types of migratory crest, they also fail to express Foxd3, but upon entry to pharyngeal arches, crest cease to transcribe Sox10, as assayed by reporter expression. They also fail to express Foxd3, but initiate expression of the ectomesenchymal marker Dlx2. What is it about the arch environment that makes crest enter the ectomesenchymal lineage? Pharyngeal epithelia are a rich source of fibroblast growth factors (FGFs), prompting the authors to test the effect of blocking FGF signaling using pharmacological reagents in zebrafish, and ectopic expression of dominant negative FGF receptors in chick. In both cases, Sox10 and Foxd3 expression are activated, and Dlx2 diminished, suggesting entry into the ectomesenchymal fate is inhibited. Oddly, other sources of FGF encountered by newly emergent crest do not activate downstream FGF effectors nor do they launch Dlx2 expression. This means there must be additional components to a pharyngeal arch elixir that enable ectomesenchymal crest to feel at ease. The versatile vertebrate (Dev Dyn 237:861–882) Twenty years ago, who could have guessed that an aquarium favorite, the zebrafish, would wriggle its way into the research limelight? Originally hailed as a valuable resource for vertebrate forward genetics, its usefulness in reverse genetics is also rapidly coming to the fore. This review is a compendium of reverse genetics techniques that has something for everyone. The zebrafish novice will value thorough coverage of commonly used methods, including procedural overview, advantages and limitations, technical tips, and research applications. The established fish researcher will appreciate reports of obscure techniques, including those that should be easily transferable to the model system. Finally, the simply curious will gain new admiration for the aquatic wonder, and may be tempted to find ways to incorporate it into their work. History comes alive (Dev Dyn 237:953–961) Over 2,000 years ago Aristotle described the developing chicken embryo as seen by the naked eye, “After three days and a night…the heart…beats and moves as if it were alive”. If he thought this sight was impressive, he would be absolutely floored by the beautiful detail depicted in the movies presented here. In the chick, blood is pumped through an endocardial tube: a lumen surrounded by inner endothelium and outer myocardium walls between which lies an extracellular matrix, called cardiac jelly. The authors imaged the pumping heart in cross-section using optical coherence tomography (OCT), which makes possible real-time, high-resolution visualization of small structures in vivo. At diastole (dilation), the tube in cross-section resembles a thick “O”: the myocardium encircles a smaller endothelium circle. At systole (contraction), a smaller myocardial “o” is nearly bisected by a slit-shaped endothelium that closes off the lumen. The observed “eccentric” deformation of the endocardial tube challenges the prevailing 60-year-old model that documents “concentric” deformation, where both walls remain circular. The potential implications of this finding are described. They also note an uneven distribution of cardiac jelly, suggesting it could be the driving force behind the shape change. Within this study, is impressive documentation of the history of this field of research, making it easy to see why this contribution is important." @default.
• W4230625089 created "2022-05-11" @default.
• W4230625089 creator A5068059715 @default.
• W4230625089 date "2008-09-01" @default.
• W4230625089 modified "2023-09-30" @default.
• W4230625089 title "Highlights inDD" @default.
• W4230625089 cites W1997693888 @default.
• W4230625089 doi "https://doi.org/10.1002/dvdy.21635" @default.
• W4230625089 hasPublicationYear "2008" @default.
• W4230625089 type Work @default.
• W4230625089 citedByCount "0" @default.
• W4230625089 crossrefType "journal-article" @default.
• W4230625089 hasAuthorship W4230625089A5068059715 @default.
• W4230625089 hasConcept C104317684 @default.
• W4230625089 hasConcept C105702510 @default.
• W4230625089 hasConcept C126749454 @default.
• W4230625089 hasConcept C127716648 @default.
• W4230625089 hasConcept C170493617 @default.
• W4230625089 hasConcept C183074962 @default.
• W4230625089 hasConcept C196843134 @default.
• W4230625089 hasConcept C2776878037 @default.
• W4230625089 hasConcept C2777302934 @default.
• W4230625089 hasConcept C2780071072 @default.
• W4230625089 hasConcept C40692019 @default.
• W4230625089 hasConcept C54355233 @default.
• W4230625089 hasConcept C74373430 @default.
• W4230625089 hasConcept C81885089 @default.
• W4230625089 hasConcept C86803240 @default.
• W4230625089 hasConcept C95444343 @default.
• W4230625089 hasConcept C97037327 @default.
• W4230625089 hasConceptScore W4230625089C104317684 @default.
• W4230625089 hasConceptScore W4230625089C105702510 @default.
• W4230625089 hasConceptScore W4230625089C126749454 @default.
• W4230625089 hasConceptScore W4230625089C127716648 @default.
• W4230625089 hasConceptScore W4230625089C170493617 @default.
• W4230625089 hasConceptScore W4230625089C183074962 @default.
• W4230625089 hasConceptScore W4230625089C196843134 @default.
• W4230625089 hasConceptScore W4230625089C2776878037 @default.
• W4230625089 hasConceptScore W4230625089C2777302934 @default.
• W4230625089 hasConceptScore W4230625089C2780071072 @default.
• W4230625089 hasConceptScore W4230625089C40692019 @default.
• W4230625089 hasConceptScore W4230625089C54355233 @default.
• W4230625089 hasConceptScore W4230625089C74373430 @default.
• W4230625089 hasConceptScore W4230625089C81885089 @default.
• W4230625089 hasConceptScore W4230625089C86803240 @default.
• W4230625089 hasConceptScore W4230625089C95444343 @default.
• W4230625089 hasConceptScore W4230625089C97037327 @default.
• W4230625089 hasIssue "9" @default.
• W4230625089 hasLocation W42306250891 @default.
• W4230625089 hasOpenAccess W4230625089 @default.
• W4230625089 hasPrimaryLocation W42306250891 @default.
• W4230625089 hasRelatedWork W1981013476 @default.
• W4230625089 hasRelatedWork W1982192259 @default.
• W4230625089 hasRelatedWork W1995581940 @default.
• W4230625089 hasRelatedWork W2000216778 @default.
• W4230625089 hasRelatedWork W2013844836 @default.
• W4230625089 hasRelatedWork W2023995963 @default.
• W4230625089 hasRelatedWork W2166884973 @default.
• W4230625089 hasRelatedWork W2463097660 @default.
• W4230625089 hasRelatedWork W2744980880 @default.
• W4230625089 hasRelatedWork W423200419 @default.
• W4230625089 hasVolume "237" @default.
• W4230625089 isParatext "false" @default.
• W4230625089 isRetracted "false" @default.
• W4230625089 workType "article" @default.