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- W4230751907 abstract "Abstract After quantitating immunoglobulins G, A, and M and complement C3c and C4 in serum by using a laser nephelometer coupled with a data processor, I compared these results with values obtained by an early-readout radial immunodiffusion method. Day-to-day precision was better for nephelometry than for radial immunodiffusion for all proteins analyzed. The average coefficient of variation was 6.0% for nephelometry and 9.9% for radial immunodiffusion. Comparison of these methods gave ranked correlation coefficients of 0.945, 0.981, 0.932, 0.803, and 0.792 for IgG, IgA, IgM, C3c, and C4, respectively. Nephelometry gave significantly higher values than radial immunodiffusion for IgG, IgA, IgM, and C3c, and significantly lower values for C4 (p less than 0.001). Part of this bias was found to be due to the equation programmed in the data processor for calculating the standard curves. Within 95% limits, nephelometry gave higher normal ranges than radial immunodiffusion for IgG, IgA, and IgM. Other possible factors that can produce this bias are discussed." @default.
- W4230751907 created "2022-05-11" @default.
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- W4230751907 date "1980-02-01" @default.
- W4230751907 modified "2023-10-14" @default.
- W4230751907 title "Comparison of radial immunodiffusion and laser nephelometry for quantitating some serum proteins." @default.
- W4230751907 doi "https://doi.org/10.1093/clinchem/26.2.0314" @default.
- W4230751907 hasPublicationYear "1980" @default.
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