Matches in SemOpenAlex for { <https://semopenalex.org/work/W4230773322> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W4230773322 endingPage "263" @default.
- W4230773322 startingPage "254" @default.
- W4230773322 abstract "B cell stimulatory factor-1 (BSF-1)/Interleukin 4 (IL 4) is a T cell product originally characterized on the basis of its actions on B lymphocytes. Recently it has been reported that BSF-1 activates T cell and mast cell lines. We now provide evidence that BSF-1, purified to homogeneity, also has a broad spectrum of activity on hematopoietic progenitor cells (HPC). However, like its action on B cells, prolierative effects were only observed when BSF-1 was combined with an additional factor. Thus BSF-1, in costimulation with recombinant G-CSF, enhances the proliferation of granulocyte-macrophage progenitor cells (CFU-GM). BSF-1 increases the proliferation of CFU-e in the presence of recombinant erythropoietin (rEPO). Furthermore, BSF-1 induces, together with rEPO, colony formation by primitive erythroid (BFU-e) and multipotent (CFU-mix) progenitor cells comparable to that observed with rEPO and interleukin 3 (IL 3). BSF-1 is also active as a megakaryocyte colony-stimulating factor; in combination with recombinant interleukin 1, rEPO or the supernatant of the T cell hybridoma FS7–20.6.18, BSF-1 induces megakaryocyte colony formation (CFU-Mk). The same factors that synergize with BSF-1 also enhance CFU-Mk proliferation induced by IL 3. Although the precise mechanisms of action of BSF-1 on HPC is not yet known, we propose that BSF-1 represents an activation factor for HPC and prepares the progenitor cells to respond to specific growth or differentiation factors." @default.
- W4230773322 created "2022-05-11" @default.
- W4230773322 creator A5013552499 @default.
- W4230773322 creator A5049528975 @default.
- W4230773322 creator A5061514448 @default.
- W4230773322 creator A5084822908 @default.
- W4230773322 date "1987-07-01" @default.
- W4230773322 modified "2023-09-30" @default.
- W4230773322 title "Effects of B cell stimulatory factor-1/interleukin 4 on hematopoietic progenitor cells" @default.
- W4230773322 doi "https://doi.org/10.1182/blood.v70.1.254.bloodjournal701254" @default.
- W4230773322 hasPublicationYear "1987" @default.
- W4230773322 type Work @default.
- W4230773322 citedByCount "0" @default.
- W4230773322 crossrefType "journal-article" @default.
- W4230773322 hasAuthorship W4230773322A5013552499 @default.
- W4230773322 hasAuthorship W4230773322A5049528975 @default.
- W4230773322 hasAuthorship W4230773322A5061514448 @default.
- W4230773322 hasAuthorship W4230773322A5084822908 @default.
- W4230773322 hasBestOaLocation W42307733221 @default.
- W4230773322 hasConcept C109159458 @default.
- W4230773322 hasConcept C131665280 @default.
- W4230773322 hasConcept C153911025 @default.
- W4230773322 hasConcept C170493617 @default.
- W4230773322 hasConcept C201750760 @default.
- W4230773322 hasConcept C2022786 @default.
- W4230773322 hasConcept C203014093 @default.
- W4230773322 hasConcept C2775960820 @default.
- W4230773322 hasConcept C2776090121 @default.
- W4230773322 hasConcept C2779705218 @default.
- W4230773322 hasConcept C28328180 @default.
- W4230773322 hasConcept C55493867 @default.
- W4230773322 hasConcept C67662055 @default.
- W4230773322 hasConcept C86803240 @default.
- W4230773322 hasConcept C8891405 @default.
- W4230773322 hasConcept C95444343 @default.
- W4230773322 hasConceptScore W4230773322C109159458 @default.
- W4230773322 hasConceptScore W4230773322C131665280 @default.
- W4230773322 hasConceptScore W4230773322C153911025 @default.
- W4230773322 hasConceptScore W4230773322C170493617 @default.
- W4230773322 hasConceptScore W4230773322C201750760 @default.
- W4230773322 hasConceptScore W4230773322C2022786 @default.
- W4230773322 hasConceptScore W4230773322C203014093 @default.
- W4230773322 hasConceptScore W4230773322C2775960820 @default.
- W4230773322 hasConceptScore W4230773322C2776090121 @default.
- W4230773322 hasConceptScore W4230773322C2779705218 @default.
- W4230773322 hasConceptScore W4230773322C28328180 @default.
- W4230773322 hasConceptScore W4230773322C55493867 @default.
- W4230773322 hasConceptScore W4230773322C67662055 @default.
- W4230773322 hasConceptScore W4230773322C86803240 @default.
- W4230773322 hasConceptScore W4230773322C8891405 @default.
- W4230773322 hasConceptScore W4230773322C95444343 @default.
- W4230773322 hasIssue "1" @default.
- W4230773322 hasLocation W42307733221 @default.
- W4230773322 hasOpenAccess W4230773322 @default.
- W4230773322 hasPrimaryLocation W42307733221 @default.
- W4230773322 hasRelatedWork W1488696575 @default.
- W4230773322 hasRelatedWork W18584205 @default.
- W4230773322 hasRelatedWork W1977973777 @default.
- W4230773322 hasRelatedWork W2025576061 @default.
- W4230773322 hasRelatedWork W2094330048 @default.
- W4230773322 hasRelatedWork W2335878673 @default.
- W4230773322 hasRelatedWork W2415656387 @default.
- W4230773322 hasRelatedWork W246905007 @default.
- W4230773322 hasRelatedWork W2003934273 @default.
- W4230773322 hasRelatedWork W2150978978 @default.
- W4230773322 hasVolume "70" @default.
- W4230773322 isParatext "false" @default.
- W4230773322 isRetracted "false" @default.
- W4230773322 workType "article" @default.