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• W4230779533 startingPage "1263" @default.
• W4230779533 abstract "The tyrosine kinase P210 is the gene product of the rearranged BCR-ABL locus on the Philadelphia chromosome (Ph1), which is found in leukemic cells of patients with chronic myelogenous leukemia. It has a weakly oncogenic effect in immature murine hematopoietic cells and does not transform NIH 3T3 cells. We have found that P210 has a strikingly different effect in Rat-1 cells, another line of established rodent fibroblasts. Stable expression of P210 in Rat-1 cells caused a distinct morphological change and conferred both tumorigenicity and capacity for anchorage-independent growth. The introduction of v-myc into Rat-1 cells expressing P210 led to complete morphological transformation and enhanced tumorigenicity. No such interaction took place in NIH 3T3 cells. Thus, Rat-1 cells can be used to detect cooperation between BCR-ABL and other oncogenes and may prove useful for the identification of secondary oncogenic events in chronic myelogenous leukemia." @default.
• W4230779533 created "2022-05-11" @default.
• W4230779533 creator A5013961573 @default.
• W4230779533 creator A5087708211 @default.
• W4230779533 date "1989-03-01" @default.
• W4230779533 modified "2023-09-28" @default.
• W4230779533 title "The BCR-ABL oncogene transforms Rat-1 cells and cooperates with v-myc" @default.
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• W4230779533 doi "https://doi.org/10.1128/mcb.9.3.1263-1270.1989" @default.
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