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- W4230781432 startingPage "2105" @default.
- W4230781432 abstract "SummaryNovelty: Novel nitrogeneous heterocyclic compounds are disclosed as antagonists of one or more of the actions of angiotensins. They may be used to treat hypertension and congestive heart failure.Biology: The angiotensin II (AII) antagonist properties were assayed in standard tests: displacement of AII binding in guinea pig adrenal gland membranes, antagonism of AII-induced contraction of isolated rabbit aorta, antagonism of AII-induced pressor responses in terminally anaesthetized or conscious rats, and stimulation of endogenous AII biosynthesis in rat, marmoset and dog on a low sodium diet given daily doses of frusemide. The specified compound gave an IC50 of 3.48 × 10−9M in the first test and an ED50 of 0.047 mg/kg in iv in the third.Chemistry: Sixteen examples are given of the preparation of the compounds by standard techniques. 2,6-Dimethyl-3-iodo-4-[(2'-(1H-tetrazol-5-yl)biphenyld-yl)methylamino]pyridine is an exemplified compound. None of the compounds is specifically claimed." @default.
- W4230781432 created "2022-05-11" @default.
- W4230781432 date "1992-12-01" @default.
- W4230781432 modified "2023-09-26" @default.
- W4230781432 title "Patent Evaluation: Nitrogen-Containing Heterocycles as Angiotensin II Antagonists" @default.
- W4230781432 cites W2013960215 @default.
- W4230781432 cites W2019220621 @default.
- W4230781432 doi "https://doi.org/10.1517/13543776.2.12.2105" @default.
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