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- W4230798905 abstract "In Brief OBJECTIVE To examine the clinical efficacy of mifepristone 100 mg followed 2 days later by misoprostol 400 μg orally or 800 μg vaginally in women at up to 49 days' gestation. METHODS Eighty participants received mifepristone 100 mg and then were randomized to misoprostol, administered 48 hours later, at a dose of 400 μg orally (group 1) or 800 μg vaginally (group 2). Women returned for follow-up evaluations 24 ± 1 hour after using the misoprostol and then 2–3 weeks later. If abortion still had not occurred and the pregnancy was nonviable, the subject returned again after an additional 3 weeks. RESULTS Twenty-four hours after receiving misoprostol, 34 (85%; 95% confidence interval [CI] 71%, 94%) of the 40 women in group 1 and 38 (95%; 95% CI 85%, 99%) of the 40 women in group 2 had complete abortions. Overall, complete abortion without surgical intervention occurred in 34 women in group 1 (85%; 95% CI 71%, 94%) and 40 women in group 2 (100%; 95% CI 91%, 100%; P = .03). Four women in group 1 required suction aspiration for continuing pregnancy at the second follow-up, compared with none in group 2 (P = .12). Side effects occurred with similar frequency in both treatment groups. CONCLUSION Low-dose mifepristone (100 mg) combined with vaginal misoprostol 800 μg may be an effective alternative to regimens using 200 or 600 mg of mifepristone with misoprostol. Low-dose mifepristone (100 mg) combined with vaginal misoprostol 800 mg may be an effective alternative to regimens using 200 or 600 mg of mifepristone plus misoprostol." @default.
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- W4230798905 date "2001-09-01" @default.
- W4230798905 modified "2023-10-17" @default.
- W4230798905 title "Mifepristone 100 mg in Abortion Regimens" @default.
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- W4230798905 doi "https://doi.org/10.1097/00006250-200109000-00013" @default.
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