FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4230800855> ?p ?o ?g. }

• W4230800855 endingPage "390" @default.
• W4230800855 startingPage "389" @default.
• W4230800855 abstract "The report of Renou et al. adds to our growing understanding of the complex epidemiology of hepatitis E virus (HEV) infection among individuals residing in industrialized countries. HEV is a single-stranded RNA virus that can be spread through contaminated drinking water, blood products, and as a zoonosis from infected animals. Acute HEV genotype 1 or 2 infection is a leading cause of acute hepatitis and jaundice worldwide as well as acute liver failure (ALF) in endemic countries, particularly in pregnant women. In addition, acute HEV has been implicated in 20%-60% of hospitalized patients presenting with acute-on-chronic liver failure (ACLF) in some developing countries.1 Sporadic acute HEV genotype 3 infection presumably transmitted from contaminated food or dairy products also accounts for some cases of icteric hepatitis in selected regions of Europe, such as Wales, Southwest France, and Denmark, but is exceedingly rare in most Western countries.2 In support of this, only 3 of the 681 (0.4%) adult Americans with ALF from our multicenter, prospective study were HEV antibody (anti-HEV) immunoglobulin (Ig) M positive over a 13-year time span, and none of our cases were pregnant nor had detectable HEV RNA.3 Other studies in the United States have also failed to implicate HEV as a significant cause of acute or chronic hepatitis in human immunodeficiency virus-positive or solid organ transplant patients. Last, the seroprevalence of detectable anti-HEV IgG is declining in the United States and other Western countries for unclear reasons. Renou et al. now report that only 3 of 181 (1.6%) hospitalized patients with decompensated alcoholic liver disease enrolled in a multicenter French cohort study had a weakly positive anti-HEV IgM, and all of them were HEV RNA negative. In addition, anti-HEV IgG seropositivity (34%) was not associated with the severity of liver disease or clinical outcomes. The findings of Renou et al. are in keeping with a recent report from the HALT-C study group that also failed to implicate unsuspected acute HEV infection as a cause of decompensation in patients with advanced hepatitis C virus fibrosis.4 Furthermore, investigators from Paris, France, recently reported that only 3 of their 84 (3.5%) hospitalized patients with severe alcoholic hepatitis had evidence of acute HEV infection, but 2 of the 3 anti-HEV IgM-positive patients had detectable HEV genotype 3 by polymerase chain reaction.5 The difference in results across studies could, in part, relate to the variable sensitivity and specificity of the serological assays used. The Beijing Wantai test is believed to have the best performance characteristics among the available assays, but additional validation studies using a World Health Organization reference sample and carefully constructed test panels are needed. We congratulate Renou et al. on their important work regarding the potential role of unsuspected HEV infection in hospitalized patients with decompensated alcoholic liver disease. However, additional studies from well-characterized cohorts of Western patients with ACLF are still needed to improve our understanding of the potential routes of transmission, pathogenesis, and clinical outcomes of previously unsuspected autochthonous HEV infection. Robert J. Fontana, M.D.1 Ronald E. Engle, M.S.2 Robert H. Purcell, M.D.2 William M. Lee, M.D.3 On behalf of the ALFSG 1Division of Gastroenterology, Department of Internal Medicine University of Michigan Medical Center Ann Arbor, MI 2National Institute of Allergy and Infectious Diseases Bethesda, MD 3University of Texas Southwestern Dallas, TX" @default.
• W4230800855 created "2022-05-11" @default.
• W4230800855 creator A5057120979 @default.
• W4230800855 creator A5063597784 @default.
• W4230800855 creator A5066896324 @default.
• W4230800855 creator A5070467866 @default.
• W4230800855 date "2016-10-06" @default.
• W4230800855 modified "2023-09-25" @default.
• W4230800855 title "Reply" @default.
• W4230800855 cites W1978017552 @default.
• W4230800855 cites W1998528600 @default.
• W4230800855 cites W2262533786 @default.
• W4230800855 cites W2401781363 @default.
• W4230800855 doi "https://doi.org/10.1002/hep.28794" @default.
• W4230800855 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27616011" @default.
• W4230800855 hasPublicationYear "2016" @default.
• W4230800855 type Work @default.
• W4230800855 citedByCount "0" @default.
• W4230800855 crossrefType "journal-article" @default.
• W4230800855 hasAuthorship W4230800855A5057120979 @default.
• W4230800855 hasAuthorship W4230800855A5063597784 @default.
• W4230800855 hasAuthorship W4230800855A5066896324 @default.
• W4230800855 hasAuthorship W4230800855A5070467866 @default.
• W4230800855 hasBestOaLocation W42308008551 @default.
• W4230800855 hasConcept C104317684 @default.
• W4230800855 hasConcept C107130276 @default.
• W4230800855 hasConcept C126322002 @default.
• W4230800855 hasConcept C135763542 @default.
• W4230800855 hasConcept C159047783 @default.
• W4230800855 hasConcept C159654299 @default.
• W4230800855 hasConcept C203014093 @default.
• W4230800855 hasConcept C2776029263 @default.
• W4230800855 hasConcept C2776353676 @default.
• W4230800855 hasConcept C2778456037 @default.
• W4230800855 hasConcept C2778494684 @default.
• W4230800855 hasConcept C2780777367 @default.
• W4230800855 hasConcept C2781096931 @default.
• W4230800855 hasConcept C3018886096 @default.
• W4230800855 hasConcept C45189115 @default.
• W4230800855 hasConcept C55493867 @default.
• W4230800855 hasConcept C71924100 @default.
• W4230800855 hasConcept C86803240 @default.
• W4230800855 hasConceptScore W4230800855C104317684 @default.
• W4230800855 hasConceptScore W4230800855C107130276 @default.
• W4230800855 hasConceptScore W4230800855C126322002 @default.
• W4230800855 hasConceptScore W4230800855C135763542 @default.
• W4230800855 hasConceptScore W4230800855C159047783 @default.
• W4230800855 hasConceptScore W4230800855C159654299 @default.
• W4230800855 hasConceptScore W4230800855C203014093 @default.
• W4230800855 hasConceptScore W4230800855C2776029263 @default.
• W4230800855 hasConceptScore W4230800855C2776353676 @default.
• W4230800855 hasConceptScore W4230800855C2778456037 @default.
• W4230800855 hasConceptScore W4230800855C2778494684 @default.
• W4230800855 hasConceptScore W4230800855C2780777367 @default.
• W4230800855 hasConceptScore W4230800855C2781096931 @default.
• W4230800855 hasConceptScore W4230800855C3018886096 @default.
• W4230800855 hasConceptScore W4230800855C45189115 @default.
• W4230800855 hasConceptScore W4230800855C55493867 @default.
• W4230800855 hasConceptScore W4230800855C71924100 @default.
• W4230800855 hasConceptScore W4230800855C86803240 @default.
• W4230800855 hasIssue "1" @default.
• W4230800855 hasLocation W42308008551 @default.
• W4230800855 hasLocation W42308008552 @default.
• W4230800855 hasLocation W42308008553 @default.
• W4230800855 hasOpenAccess W4230800855 @default.
• W4230800855 hasPrimaryLocation W42308008551 @default.
• W4230800855 hasRelatedWork W1537472804 @default.
• W4230800855 hasRelatedWork W1567329417 @default.
• W4230800855 hasRelatedWork W2024186628 @default.
• W4230800855 hasRelatedWork W2089562418 @default.
• W4230800855 hasRelatedWork W2108605645 @default.
• W4230800855 hasRelatedWork W2146636699 @default.
• W4230800855 hasRelatedWork W2187866299 @default.
• W4230800855 hasRelatedWork W2988186049 @default.
• W4230800855 hasRelatedWork W3191284643 @default.
• W4230800855 hasRelatedWork W4243551239 @default.
• W4230800855 hasVolume "65" @default.
• W4230800855 isParatext "false" @default.
• W4230800855 isRetracted "false" @default.
• W4230800855 workType "article" @default.