Matches in SemOpenAlex for { <https://semopenalex.org/work/W4230838568> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W4230838568 endingPage "424" @default.
- W4230838568 startingPage "419" @default.
- W4230838568 abstract "Meningioma is a common tumor of the meninges covering the central nervous system. Although generally a benign tumor, meningioma often recurs and is malignant in 5–10% of all cases. Loss of chromosome 22 loci, and specifically inactivation of the NF2 tumor suppressor gene, is considered one of several critical steps in the tumorigenesis of meningioma. However, cytogenetic and molecular investigations have failed to detect either aberrations of chromosome 22 or mutations in the NF2 gene in approximately 40% of all tumors, thus making it apparent that an alternative mechanism(s) is responsible for the development of a large fraction of meningiomas. This subset of meningiomas is not distinct with regard to clinical and histopathological features from tumors showing deletions on chromosome 22. It is, therefore, important to attempt the elucidation of molecular pathway(s) that may operate in the tumorigenesis of these tumors. We used comparative genomic hybridization (CGH) to identify regions of the genome other than chromosome 22, contributing to the development of meningioma. We analyzed 25 tumors that had undergone detailed LOH analysis on chromosome 22 and were shown to contain no detectable deletions. Two benign, malignancy grade I, meningiomas showed concurrent deletion of 1p and 3p. These results suggest that loss of both 1p and 3p may contribute to meningioma tumorigenesis. This may represent genetic changes that are alternative to deletions on chromosome 22. Genes Chromosomes Cancer 20:419–424, 1997. © 1997 Wiley-Liss, Inc." @default.
- W4230838568 created "2022-05-11" @default.
- W4230838568 creator A5022577576 @default.
- W4230838568 creator A5031149412 @default.
- W4230838568 creator A5056300510 @default.
- W4230838568 creator A5062305344 @default.
- W4230838568 date "1997-12-01" @default.
- W4230838568 modified "2023-09-25" @default.
- W4230838568 title "1p and 3p deletions in meningiomas without detectable aberrations of chromosome 22 identified by comparative genomic hybridization" @default.
- W4230838568 doi "https://doi.org/10.1002/(sici)1098-2264(199712)20:4<419::aid-gcc15>3.3.co;2-z" @default.
- W4230838568 hasPublicationYear "1997" @default.
- W4230838568 type Work @default.
- W4230838568 citedByCount "1" @default.
- W4230838568 crossrefType "journal-article" @default.
- W4230838568 hasAuthorship W4230838568A5022577576 @default.
- W4230838568 hasAuthorship W4230838568A5031149412 @default.
- W4230838568 hasAuthorship W4230838568A5056300510 @default.
- W4230838568 hasAuthorship W4230838568A5062305344 @default.
- W4230838568 hasConcept C104317684 @default.
- W4230838568 hasConcept C124942203 @default.
- W4230838568 hasConcept C142724271 @default.
- W4230838568 hasConcept C2779160599 @default.
- W4230838568 hasConcept C2779399171 @default.
- W4230838568 hasConcept C2780045450 @default.
- W4230838568 hasConcept C30481170 @default.
- W4230838568 hasConcept C502942594 @default.
- W4230838568 hasConcept C54355233 @default.
- W4230838568 hasConcept C54815482 @default.
- W4230838568 hasConcept C555283112 @default.
- W4230838568 hasConcept C71924100 @default.
- W4230838568 hasConcept C86803240 @default.
- W4230838568 hasConceptScore W4230838568C104317684 @default.
- W4230838568 hasConceptScore W4230838568C124942203 @default.
- W4230838568 hasConceptScore W4230838568C142724271 @default.
- W4230838568 hasConceptScore W4230838568C2779160599 @default.
- W4230838568 hasConceptScore W4230838568C2779399171 @default.
- W4230838568 hasConceptScore W4230838568C2780045450 @default.
- W4230838568 hasConceptScore W4230838568C30481170 @default.
- W4230838568 hasConceptScore W4230838568C502942594 @default.
- W4230838568 hasConceptScore W4230838568C54355233 @default.
- W4230838568 hasConceptScore W4230838568C54815482 @default.
- W4230838568 hasConceptScore W4230838568C555283112 @default.
- W4230838568 hasConceptScore W4230838568C71924100 @default.
- W4230838568 hasConceptScore W4230838568C86803240 @default.
- W4230838568 hasIssue "4" @default.
- W4230838568 hasLocation W42308385681 @default.
- W4230838568 hasOpenAccess W4230838568 @default.
- W4230838568 hasPrimaryLocation W42308385681 @default.
- W4230838568 hasRelatedWork W1984029756 @default.
- W4230838568 hasRelatedWork W1989622889 @default.
- W4230838568 hasRelatedWork W2031436818 @default.
- W4230838568 hasRelatedWork W2037855880 @default.
- W4230838568 hasRelatedWork W2052975138 @default.
- W4230838568 hasRelatedWork W205979824 @default.
- W4230838568 hasRelatedWork W2088884262 @default.
- W4230838568 hasRelatedWork W2119103177 @default.
- W4230838568 hasRelatedWork W2161085873 @default.
- W4230838568 hasRelatedWork W2288281514 @default.
- W4230838568 hasVolume "20" @default.
- W4230838568 isParatext "false" @default.
- W4230838568 isRetracted "false" @default.
- W4230838568 workType "article" @default.