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• W4230852093 abstract "Comprehensive delineation of complex cellular networks requires high-throughput interrogation of genetic interactions. To address this challenge, we describe the development of a multiplex combinatorial strategy to assess pairwise genetic interactions using CRISPR-Cas9 genome editing and next-generation sequencing. We characterize the performance of combinatorial genome editing and analysis using different promoter and gRNA designs and identified regions of the chimeric RNA that are compatible with next-generation sequencing preparation and quantification. This approach is an important step towards elucidating genetic networks relevant to human diseases and the development of more efficient Cas9-based therapeutics." @default.
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• W4230852093 date "2016-12-09" @default.
• W4230852093 modified "2023-10-14" @default.
• W4230852093 title "A High-Throughput Strategy for Dissecting Mammalian Genetic Interactions" @default.
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• W4230852093 doi "https://doi.org/10.1371/journal.pone.0167617" @default.
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