FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4230884203> ?p ?o ?g. }

• W4230884203 endingPage "213" @default.
• W4230884203 startingPage "206" @default.
• W4230884203 abstract "Dexdor® do not include the possibility of loading dose, which could increase time to achieve adequate sedation for ambulatory procedures. The objective of this study was to evaluate the effect of several loading dose of dexmedetomidine in the time to achieve and maintain an optimal level of sedation and its clinical haemodynamic repercussion. The IRB approved this observational study for patients that underwent oral and maxillofacial ambulatory surgery under dexmedetomidine at the University of Navarra Clinic from February 2013 to November 2014. According to the loading dose the patients were grouped into 3 categories: <0.5, 0.5, and >0.5 μg/kg. Optimal level of sedation was defined as bispectral index <85. Data were analyzed using survival analysis techniques. Vasoactive drugs requirements were evaluated using exact logistic regression. Eighty-one patients were evaluated. Hazard ratios for patients in 0.5 and >0.5 μg/kg loading dose categories for achieving a bispectral index <85 were 1.5 (95% CI 0.9, 2.6) and 1.8 (95% CI 0.8, 3.9), respectively, compared with the lowest category. Five patients (6.2%) required atropine for bradycardia. Patients in the group >0.5 μg/kg showed greater risk of requiring atropine compared with the group <0.5 μg/kg (odds ratio 2.2; 95% CI 0.03, 183). Loading dose of dexmedetomidine >0.5 μg/kg appears minimize the time to achieve and maintain an optimal level of sedation during the first 60 min of procedure. Further investigation to elucidate the association between loading dose of dexmedetomidine and subsequent atropine requirements may be warranted. El objetivo de este estudio fue evaluar el efecto de diferentes dosis de carga de dexmedetomidina (formulación Dexdor®) en el tiempo para lograr y mantener un nivel óptimo de sedación, y su repercusión hemodinámica. Estudio observacional aprobado por el CEIC-Navarra en pacientes programados para cirugía oral y maxilofacial ambulatoria con dexmedetomidina en la Clínica Universidad de Navarra entre febrero de 2013 y noviembre de 2014. En función de la dosis de carga los pacientes fueron agrupados en 3 categorías: <0,5; 0,5; y > 0,5 μg/kg. El nivel óptimo de sedación se definió como un índice biespectral < 85. Los datos se analizaron utilizando técnicas de análisis de supervivencia. Los requerimientos de fármacos vasoactivos fueron evaluados mediante regresión logística exacta. Ochenta y un pacientes fueron evaluados. La hazard ratio de alcanzar un índice biespectral < 85 para los pacientes de los grupos de 0,5 y > 0,5 μg/kg fue de 1,5 (IC 95% 0,9; 2,6) y 1,8 (IC 95% 0,8; 3,9), respectivamente, en comparación con el grupo inferior. Cinco pacientes (6,2%) precisaron de atropina. Los pacientes en el grupo de > 0,5 μg/kg mostraron mayor riesgo de requerir atropina respecto al grupo de < 0,5 μg/kg (odds ratio 2,2; IC 95% 0,03; 183). Una dosis de carga de Dexdor® > 0,5 μg/kg parece reducir el tiempo necesario para alcanzar y mantener un nivel óptimo de sedación durante los primeros 60 min de procedimiento. La posible relación entre la dosis de carga y los requerimientos de atropina precisa una investigación más exhaustiva." @default.
• W4230884203 created "2022-05-11" @default.
• W4230884203 creator A5017363126 @default.
• W4230884203 creator A5028616785 @default.
• W4230884203 creator A5050865533 @default.
• W4230884203 creator A5055907963 @default.
• W4230884203 creator A5063192604 @default.
• W4230884203 creator A5069596223 @default.
• W4230884203 creator A5081693325 @default.
• W4230884203 date "2017-04-01" @default.
• W4230884203 modified "2023-10-18" @default.
• W4230884203 title "Loading dose of Dexdor ® and optimal sedation during oral and maxillofacial ambulatory surgery procedures: An observational study" @default.
• W4230884203 cites W1505219599 @default.
• W4230884203 cites W1970159767 @default.
• W4230884203 cites W1971101248 @default.
• W4230884203 cites W1972649294 @default.
• W4230884203 cites W1976961937 @default.
• W4230884203 cites W1979832931 @default.
• W4230884203 cites W1983852718 @default.
• W4230884203 cites W1997421395 @default.
• W4230884203 cites W2014862451 @default.
• W4230884203 cites W2021603865 @default.
• W4230884203 cites W2026929589 @default.
• W4230884203 cites W2036354810 @default.
• W4230884203 cites W2047727428 @default.
• W4230884203 cites W2060486687 @default.
• W4230884203 cites W2062926697 @default.
• W4230884203 cites W2067164747 @default.
• W4230884203 cites W2085355231 @default.
• W4230884203 cites W2104645833 @default.
• W4230884203 cites W2118828741 @default.
• W4230884203 cites W2128375328 @default.
• W4230884203 cites W2130911894 @default.
• W4230884203 cites W2142919115 @default.
• W4230884203 cites W2146885782 @default.
• W4230884203 cites W2168312394 @default.
• W4230884203 cites W2171436446 @default.
• W4230884203 cites W2319529606 @default.
• W4230884203 doi "https://doi.org/10.1016/j.redare.2017.02.003" @default.
• W4230884203 hasPublicationYear "2017" @default.
• W4230884203 type Work @default.
• W4230884203 citedByCount "0" @default.
• W4230884203 crossrefType "journal-article" @default.
• W4230884203 hasAuthorship W4230884203A5017363126 @default.
• W4230884203 hasAuthorship W4230884203A5028616785 @default.
• W4230884203 hasAuthorship W4230884203A5050865533 @default.
• W4230884203 hasAuthorship W4230884203A5055907963 @default.
• W4230884203 hasAuthorship W4230884203A5063192604 @default.
• W4230884203 hasAuthorship W4230884203A5069596223 @default.
• W4230884203 hasAuthorship W4230884203A5081693325 @default.
• W4230884203 hasConcept C126322002 @default.
• W4230884203 hasConcept C141071460 @default.
• W4230884203 hasConcept C156957248 @default.
• W4230884203 hasConcept C23131810 @default.
• W4230884203 hasConcept C2776814716 @default.
• W4230884203 hasConcept C2777495988 @default.
• W4230884203 hasConcept C2777953023 @default.
• W4230884203 hasConcept C2781302539 @default.
• W4230884203 hasConcept C35294091 @default.
• W4230884203 hasConcept C35785553 @default.
• W4230884203 hasConcept C42219234 @default.
• W4230884203 hasConcept C71924100 @default.
• W4230884203 hasConcept C84393581 @default.
• W4230884203 hasConceptScore W4230884203C126322002 @default.
• W4230884203 hasConceptScore W4230884203C141071460 @default.
• W4230884203 hasConceptScore W4230884203C156957248 @default.
• W4230884203 hasConceptScore W4230884203C23131810 @default.
• W4230884203 hasConceptScore W4230884203C2776814716 @default.
• W4230884203 hasConceptScore W4230884203C2777495988 @default.
• W4230884203 hasConceptScore W4230884203C2777953023 @default.
• W4230884203 hasConceptScore W4230884203C2781302539 @default.
• W4230884203 hasConceptScore W4230884203C35294091 @default.
• W4230884203 hasConceptScore W4230884203C35785553 @default.
• W4230884203 hasConceptScore W4230884203C42219234 @default.
• W4230884203 hasConceptScore W4230884203C71924100 @default.
• W4230884203 hasConceptScore W4230884203C84393581 @default.
• W4230884203 hasIssue "4" @default.
• W4230884203 hasLocation W42308842031 @default.
• W4230884203 hasOpenAccess W4230884203 @default.
• W4230884203 hasPrimaryLocation W42308842031 @default.
• W4230884203 hasRelatedWork W2126545071 @default.
• W4230884203 hasRelatedWork W2304899317 @default.
• W4230884203 hasRelatedWork W2520630385 @default.
• W4230884203 hasRelatedWork W2588523905 @default.
• W4230884203 hasRelatedWork W2767349675 @default.
• W4230884203 hasRelatedWork W2894864250 @default.
• W4230884203 hasRelatedWork W2913741303 @default.
• W4230884203 hasRelatedWork W3030146355 @default.
• W4230884203 hasRelatedWork W3153296609 @default.
• W4230884203 hasRelatedWork W3155559497 @default.
• W4230884203 hasVolume "64" @default.
• W4230884203 isParatext "false" @default.
• W4230884203 isRetracted "false" @default.
• W4230884203 workType "article" @default.