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- W4230902061 abstract "The CA 50 antigen is defined by the monoclonal antibody C 50 (IgM) obtained by immunization of mice with the human colonic adenocarcinoma cell line COLO 205 (Lindholm et al., 1983). The C 50 antibody reacts with an epitope present on two carbohydrate moieties, sialosylfucosyllactotetraose (IV3NeuAc,III4FucLcOse4) (Månsson et al., 1985), corresponding to sialylated Lewisa blood group antigen, and sialosyllactotetraose (IV3NeuAc-LcOse4), lacking the fucose molecule of the sialylated Lewisa structure (Nilsson et al., 1985). The CA 50 antigen occurs mainly on glycoproteins in serum and in tissues also as gangliosides (Nilsson et al., 1983,1985). Normally, sialylated Lewisa is the dominant CA 50 ganglioside in epithelial carcinomas (Månsson et al., 1985). Sialosyllactotetraose has been found in small amounts in various carcinomas (Nilsson et al., 1983, 1985), but, determined by a solid-phase assay, the reactivity of the C 50 antibody for sialosyllactotetraose is one-tenth of that for sialylated Lewisa (Nilsson et al.,1985). Sialylated Lewisa is also the antigenic epitope in another tumor marker test, the CA 19–9 assay, based on the monoclonal antibody 1116 NS 19–9 (Koprowski et al., 1979; Magnani et al., 1982)." @default.
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- W4230902061 date "1992-01-01" @default.
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- W4230902061 title "CA 50" @default.
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- W4230902061 doi "https://doi.org/10.1007/978-1-4612-0401-5_17" @default.
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