FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4230995102> ?p ?o ?g. }

• W4230995102 endingPage "1305" @default.
• W4230995102 startingPage "1296" @default.
• W4230995102 abstract "Both transcription initiation and transcription elongation contribute to the regulation of steady-state c-myc RNA levels. We have used the Xenopus oocyte transcription assay to study premature transcription termination which occurs in the first exon and intron of the human c-myc gene. Previous studies showed that after injection into Xenopus oocytes transcription from the c-myc P1 promoter resulted in read-through transcripts whereas transcription from the stronger P2 promoter resulted in a combination of prematurely terminated and read-through transcripts. We now demonstrate that this promoter-specific processivity results from the overall amount of RNA polymerase II transcription occurring from either promoter. Parameters that reduce the amount of transcription from P1 or P2, such as decreased concentration of template injected or decreased incubation time, result in a reduction in the ratio of terminated to read-through c-myc transcripts. Conversely, when transcription levels are increased by higher concentrations of injected template, increased incubation time, or coinjection with competing template, the ratio of terminated to read-through transcripts increases. We hypothesize that an RNA polymerase II processivity function is depleted above a threshold level of transcription initiation, resulting in high levels of premature transcription termination. These findings account for the promoter-specific effects on transcription elongation previously seen in this assay system and suggest a mechanism whereby limiting transcription elongation factors may contribute to transcription regulation in other eukaryotic cells." @default.
• W4230995102 created "2022-05-11" @default.
• W4230995102 creator A5025294351 @default.
• W4230995102 creator A5067029467 @default.
• W4230995102 date "1993-02-01" @default.
• W4230995102 modified "2023-09-24" @default.
• W4230995102 title "Transcription elongation in the human c-myc gene is governed by overall transcription initiation levels in Xenopus oocytes" @default.
• W4230995102 cites W1411639921 @default.
• W4230995102 cites W1495272934 @default.
• W4230995102 cites W1533478806 @default.
• W4230995102 cites W1563789995 @default.
• W4230995102 cites W1569390933 @default.
• W4230995102 cites W1570974013 @default.
• W4230995102 cites W1572773280 @default.
• W4230995102 cites W1574548557 @default.
• W4230995102 cites W1595785723 @default.
• W4230995102 cites W1844500634 @default.
• W4230995102 cites W1881038850 @default.
• W4230995102 cites W1953380675 @default.
• W4230995102 cites W1966425882 @default.
• W4230995102 cites W1967615956 @default.
• W4230995102 cites W1978539107 @default.
• W4230995102 cites W1984688123 @default.
• W4230995102 cites W1988625317 @default.
• W4230995102 cites W1995302894 @default.
• W4230995102 cites W1996164869 @default.
• W4230995102 cites W1996916737 @default.
• W4230995102 cites W2011039989 @default.
• W4230995102 cites W2019895401 @default.
• W4230995102 cites W2023491365 @default.
• W4230995102 cites W2028323670 @default.
• W4230995102 cites W2029375782 @default.
• W4230995102 cites W2050797066 @default.
• W4230995102 cites W2077853107 @default.
• W4230995102 cites W2079819430 @default.
• W4230995102 cites W2086584161 @default.
• W4230995102 cites W2093428365 @default.
• W4230995102 cites W2107624922 @default.
• W4230995102 cites W2114491118 @default.
• W4230995102 cites W2117445809 @default.
• W4230995102 cites W2125131118 @default.
• W4230995102 cites W2148039214 @default.
• W4230995102 cites W245337638 @default.
• W4230995102 cites W84461096 @default.
• W4230995102 cites W94613862 @default.
• W4230995102 doi "https://doi.org/10.1128/mcb.13.2.1296-1305.1993" @default.
• W4230995102 hasPublicationYear "1993" @default.
• W4230995102 type Work @default.
• W4230995102 citedByCount "0" @default.
• W4230995102 crossrefType "journal-article" @default.
• W4230995102 hasAuthorship W4230995102A5025294351 @default.
• W4230995102 hasAuthorship W4230995102A5067029467 @default.
• W4230995102 hasConcept C101762097 @default.
• W4230995102 hasConcept C104317684 @default.
• W4230995102 hasConcept C105208137 @default.
• W4230995102 hasConcept C132376346 @default.
• W4230995102 hasConcept C138885662 @default.
• W4230995102 hasConcept C144825837 @default.
• W4230995102 hasConcept C150194340 @default.
• W4230995102 hasConcept C153911025 @default.
• W4230995102 hasConcept C154816499 @default.
• W4230995102 hasConcept C156951783 @default.
• W4230995102 hasConcept C172768829 @default.
• W4230995102 hasConcept C179926584 @default.
• W4230995102 hasConcept C2779535977 @default.
• W4230995102 hasConcept C41895202 @default.
• W4230995102 hasConcept C44498088 @default.
• W4230995102 hasConcept C54355233 @default.
• W4230995102 hasConcept C64350747 @default.
• W4230995102 hasConcept C76753757 @default.
• W4230995102 hasConcept C86339819 @default.
• W4230995102 hasConcept C86803240 @default.
• W4230995102 hasConcept C95444343 @default.
• W4230995102 hasConceptScore W4230995102C101762097 @default.
• W4230995102 hasConceptScore W4230995102C104317684 @default.
• W4230995102 hasConceptScore W4230995102C105208137 @default.
• W4230995102 hasConceptScore W4230995102C132376346 @default.
• W4230995102 hasConceptScore W4230995102C138885662 @default.
• W4230995102 hasConceptScore W4230995102C144825837 @default.
• W4230995102 hasConceptScore W4230995102C150194340 @default.
• W4230995102 hasConceptScore W4230995102C153911025 @default.
• W4230995102 hasConceptScore W4230995102C154816499 @default.
• W4230995102 hasConceptScore W4230995102C156951783 @default.
• W4230995102 hasConceptScore W4230995102C172768829 @default.
• W4230995102 hasConceptScore W4230995102C179926584 @default.
• W4230995102 hasConceptScore W4230995102C2779535977 @default.
• W4230995102 hasConceptScore W4230995102C41895202 @default.
• W4230995102 hasConceptScore W4230995102C44498088 @default.
• W4230995102 hasConceptScore W4230995102C54355233 @default.
• W4230995102 hasConceptScore W4230995102C64350747 @default.
• W4230995102 hasConceptScore W4230995102C76753757 @default.
• W4230995102 hasConceptScore W4230995102C86339819 @default.
• W4230995102 hasConceptScore W4230995102C86803240 @default.
• W4230995102 hasConceptScore W4230995102C95444343 @default.
• W4230995102 hasIssue "2" @default.
• W4230995102 hasLocation W42309951021 @default.
• W4230995102 hasOpenAccess W4230995102 @default.
• W4230995102 hasPrimaryLocation W42309951021 @default.

• next