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- W4231004015 abstract "Abstract Chronic lymphocytic leukemia (CLL) is a malignancy of mature B cells that depend on host factors in the tissue microenvironment for survival and proliferation. In vitro, CLL cells rapidly undergo apoptosis unless microenvironmental factors are provided that support their survival. Signaling pathways activated in the microenvironment in vivo include the B-cell receptor (BCR) and NF-κB pathways. Thus, CLL is a disease “addicted to the host” and is dependent on pathways that promote normal B-cell development, expansion, and survival; this is particularly true in the case of the BCR signaling cascade. Small-molecule inhibitors of kinases that are essential for BCR signal transduction abrogate the stimulating effects of the microenvironment on CLL cells. The orally administered tyrosine kinase inhibitors fostamatinib and ibrutinib and the phosphatidylinositol 3-kinase inhibitor GS-1101 have induced impressive responses in relapsed and refractory CLL patients, mostly with moderate side effects. Reductions in lymphadenopathy and splenomegaly are seen within weeks and are frequently accompanied by a transient rise in absolute lymphocyte count that is asymptomatic and probably the result of changes in CLL cell trafficking. This review discusses the biologic basis for kinase inhibitors as targeted therapy of CLL and summarizes the exciting early clinical experience with these agents." @default.
- W4231004015 created "2022-05-11" @default.
- W4231004015 creator A5030524385 @default.
- W4231004015 date "2012-12-08" @default.
- W4231004015 modified "2023-10-18" @default.
- W4231004015 title "Emerging role of kinase-targeted strategies in chronic lymphocytic leukemia" @default.
- W4231004015 cites W1531083786 @default.
- W4231004015 cites W1551073524 @default.
- W4231004015 cites W1785108662 @default.
- W4231004015 cites W1970400561 @default.
- W4231004015 cites W1972593274 @default.
- W4231004015 cites W1974922046 @default.
- W4231004015 cites W1976058906 @default.
- W4231004015 cites W1976174817 @default.
- W4231004015 cites W1976402300 @default.
- W4231004015 cites W1979816280 @default.
- W4231004015 cites W1979918288 @default.
- W4231004015 cites W1984046622 @default.
- W4231004015 cites W1984147944 @default.
- W4231004015 cites W1989593746 @default.
- W4231004015 cites W1990159135 @default.
- W4231004015 cites W1990986028 @default.
- W4231004015 cites W1991795177 @default.
- W4231004015 cites W1993986769 @default.
- W4231004015 cites W1996541484 @default.
- W4231004015 cites W2005150159 @default.
- W4231004015 cites W2007886976 @default.
- W4231004015 cites W2011950935 @default.
- W4231004015 cites W2017341404 @default.
- W4231004015 cites W2019216438 @default.
- W4231004015 cites W2019655196 @default.
- W4231004015 cites W2025786205 @default.
- W4231004015 cites W2027971058 @default.
- W4231004015 cites W2034623756 @default.
- W4231004015 cites W2036758696 @default.
- W4231004015 cites W2038053631 @default.
- W4231004015 cites W2038678963 @default.
- W4231004015 cites W2040570751 @default.
- W4231004015 cites W2040604274 @default.
- W4231004015 cites W2052894538 @default.
- W4231004015 cites W2055091448 @default.
- W4231004015 cites W2057370954 @default.
- W4231004015 cites W2058786179 @default.
- W4231004015 cites W2065338378 @default.
- W4231004015 cites W2066027952 @default.
- W4231004015 cites W2066815159 @default.
- W4231004015 cites W2070232733 @default.
- W4231004015 cites W2072162251 @default.
- W4231004015 cites W2074978411 @default.
- W4231004015 cites W2075875145 @default.
- W4231004015 cites W2077813812 @default.
- W4231004015 cites W2078493126 @default.
- W4231004015 cites W2078673494 @default.
- W4231004015 cites W2079008596 @default.
- W4231004015 cites W2080766669 @default.
- W4231004015 cites W2087653208 @default.
- W4231004015 cites W2093538016 @default.
- W4231004015 cites W2095430934 @default.
- W4231004015 cites W2095726706 @default.
- W4231004015 cites W2098166849 @default.
- W4231004015 cites W2109442096 @default.
- W4231004015 cites W2111609050 @default.
- W4231004015 cites W2113278680 @default.
- W4231004015 cites W2118084423 @default.
- W4231004015 cites W2119374469 @default.
- W4231004015 cites W2120963630 @default.
- W4231004015 cites W2121510983 @default.
- W4231004015 cites W2128631476 @default.
- W4231004015 cites W2134645992 @default.
- W4231004015 cites W2142099365 @default.
- W4231004015 cites W2143790526 @default.
- W4231004015 cites W2146029333 @default.
- W4231004015 cites W2154022654 @default.
- W4231004015 cites W2154992334 @default.
- W4231004015 cites W2163690533 @default.
- W4231004015 cites W2166526425 @default.
- W4231004015 cites W2168215118 @default.
- W4231004015 cites W2590636514 @default.
- W4231004015 cites W2602813562 @default.
- W4231004015 doi "https://doi.org/10.1182/asheducation.v2012.1.88.3801172" @default.
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