Matches in SemOpenAlex for { <https://semopenalex.org/work/W4231014311> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W4231014311 endingPage "7" @default.
- W4231014311 startingPage "1" @default.
- W4231014311 abstract "Study of amino acid transport in the intestine of higher animal, which had initiated into the concept of active transport and entertained the classical hypothesis of protein absorption in animal intestine, is still at a fairly primitive sgage of investigation. The present report reviews current status of knowledge and research results from the author's laboratory in this field, and aims to call readers' attention to the opportunity for definitive experiments with animal intestine. Nε-substituted L-lysine derivatives were found nontransportable and to inhibit competitively the transport of basic amino acids but entirely not of the neutral amino acid. The results were interpreted indicating the separateness of the substrate recognition and translocation processes involved in the transport mechanism. Evidence is reviewed for incompleteness of stereospecificity of transport mechanism. Those amino acids previously known to support growth and to maintain N balance in place of their L-isomers in animal nutrition were found among those amino acids which could induce positive transport potential and could be actively taken up by the intestine; the results are implicit that active transportability constitutes a prerequisite for effective utilization. Selected examples are discussed of changes in intestinal functions with different dietary conditions including semistarvation, feeding on diets containing one or two amino acids in excess of animal requirement, and daily rhythmic changes in meal-fed rats. Transport of both D- and L-isomers of various amino acids so far tested increased impartially after semistarvation. Kinetic analyses revealed that semistarvation induceda greater increase in maximum transport capacity but least effect on the affinity of the trans-port mechanisms. On the other hands excessive administration of certain amino acid lead to increase transport for the amino acid in concern; results can be regarded as an induction by the substrate amino acid. Daily rhythm of the transport mechanism was found synchronized to the time of feeding and to be possibly entrained by those rhythms occurring in the epithelial cells (protein synthesis). Some unanswered questions are reviewed regarding peptide transport in the intestine. And the emphasis is given to assess quantitative importance as well as to elucidate absorption mechanism(s) of peptide absorption, and to conduct experiments with peptide along the line of studies already carried out with amino acids." @default.
- W4231014311 created "2022-05-11" @default.
- W4231014311 creator A5087170624 @default.
- W4231014311 date "1978-01-01" @default.
- W4231014311 modified "2023-09-27" @default.
- W4231014311 title "Active Transport of Amino Acids-Intestinal Absorption in Higher Animals" @default.
- W4231014311 doi "https://doi.org/10.2142/biophys.18.1" @default.
- W4231014311 hasPublicationYear "1978" @default.
- W4231014311 type Work @default.
- W4231014311 citedByCount "0" @default.
- W4231014311 crossrefType "journal-article" @default.
- W4231014311 hasAuthorship W4231014311A5087170624 @default.
- W4231014311 hasBestOaLocation W42310143111 @default.
- W4231014311 hasConcept C111472728 @default.
- W4231014311 hasConcept C121332964 @default.
- W4231014311 hasConcept C125287762 @default.
- W4231014311 hasConcept C138885662 @default.
- W4231014311 hasConcept C185592680 @default.
- W4231014311 hasConcept C197683979 @default.
- W4231014311 hasConcept C24890656 @default.
- W4231014311 hasConcept C2776016237 @default.
- W4231014311 hasConcept C2777882243 @default.
- W4231014311 hasConcept C515207424 @default.
- W4231014311 hasConcept C55493867 @default.
- W4231014311 hasConcept C62231903 @default.
- W4231014311 hasConcept C86803240 @default.
- W4231014311 hasConcept C89611455 @default.
- W4231014311 hasConceptScore W4231014311C111472728 @default.
- W4231014311 hasConceptScore W4231014311C121332964 @default.
- W4231014311 hasConceptScore W4231014311C125287762 @default.
- W4231014311 hasConceptScore W4231014311C138885662 @default.
- W4231014311 hasConceptScore W4231014311C185592680 @default.
- W4231014311 hasConceptScore W4231014311C197683979 @default.
- W4231014311 hasConceptScore W4231014311C24890656 @default.
- W4231014311 hasConceptScore W4231014311C2776016237 @default.
- W4231014311 hasConceptScore W4231014311C2777882243 @default.
- W4231014311 hasConceptScore W4231014311C515207424 @default.
- W4231014311 hasConceptScore W4231014311C55493867 @default.
- W4231014311 hasConceptScore W4231014311C62231903 @default.
- W4231014311 hasConceptScore W4231014311C86803240 @default.
- W4231014311 hasConceptScore W4231014311C89611455 @default.
- W4231014311 hasIssue "1" @default.
- W4231014311 hasLocation W42310143111 @default.
- W4231014311 hasOpenAccess W4231014311 @default.
- W4231014311 hasPrimaryLocation W42310143111 @default.
- W4231014311 hasRelatedWork W1927591950 @default.
- W4231014311 hasRelatedWork W1993795649 @default.
- W4231014311 hasRelatedWork W2080613476 @default.
- W4231014311 hasRelatedWork W2081940762 @default.
- W4231014311 hasRelatedWork W2093059412 @default.
- W4231014311 hasRelatedWork W2124586696 @default.
- W4231014311 hasRelatedWork W2139232831 @default.
- W4231014311 hasRelatedWork W2282413384 @default.
- W4231014311 hasRelatedWork W2411369267 @default.
- W4231014311 hasRelatedWork W8259009 @default.
- W4231014311 hasVolume "18" @default.
- W4231014311 isParatext "false" @default.
- W4231014311 isRetracted "false" @default.
- W4231014311 workType "article" @default.