Matches in SemOpenAlex for { <https://semopenalex.org/work/W4231067112> ?p ?o ?g. }
Showing items 1 to 54 of
54
with 100 items per page.
- W4231067112 endingPage "340" @default.
- W4231067112 startingPage "338" @default.
- W4231067112 abstract "TYBAMATE is a chemical analogue of meprobamate which shares many of the pharmacological properties of the latter drug (Figure). These properties include sedative, anticonvulsant, and musclerelaxant effects. Tybamate differs from meprobamate in that it reverses the electroencephalographic activation produced by lysergic acid diethylamide tartrate (LSD-25) in rabbits, antagonizes the rise in blood pressure induced by serotonin in dogs, and is extensively bound to protein.<sup>1</sup>A number of clinical reports, including some double-blind comparisons with placebo and meprobamate, attest to its clinical efficacy.<sup>2,3</sup>Despite considerable clinical use, so far no instances of withdrawal reactions have been encountered. Early investigations suggested freedom from withdrawal effects. Even when administered over a long period of time to dogs in doses of 570 mg/kg of body weight; no withdrawal seizures were encountered; dogs treated with comparable doses of meprobamate had frequent withdrawal seizures, often fatal.<sup>4</sup> As canine withdrawal reactions have correlated well" @default.
- W4231067112 created "2022-05-11" @default.
- W4231067112 creator A5035135931 @default.
- W4231067112 date "1967-01-30" @default.
- W4231067112 modified "2023-09-26" @default.
- W4231067112 title "Simulated abuse of tybamate in man. Failure to demonstrate withdrawal reactions" @default.
- W4231067112 doi "https://doi.org/10.1001/jama.199.5.338" @default.
- W4231067112 hasPublicationYear "1967" @default.
- W4231067112 type Work @default.
- W4231067112 citedByCount "0" @default.
- W4231067112 crossrefType "journal-article" @default.
- W4231067112 hasAuthorship W4231067112A5035135931 @default.
- W4231067112 hasConcept C118552586 @default.
- W4231067112 hasConcept C142724271 @default.
- W4231067112 hasConcept C204787440 @default.
- W4231067112 hasConcept C27081682 @default.
- W4231067112 hasConcept C2775858608 @default.
- W4231067112 hasConcept C2777602617 @default.
- W4231067112 hasConcept C2777937089 @default.
- W4231067112 hasConcept C2778186239 @default.
- W4231067112 hasConcept C42219234 @default.
- W4231067112 hasConcept C71924100 @default.
- W4231067112 hasConcept C98274493 @default.
- W4231067112 hasConceptScore W4231067112C118552586 @default.
- W4231067112 hasConceptScore W4231067112C142724271 @default.
- W4231067112 hasConceptScore W4231067112C204787440 @default.
- W4231067112 hasConceptScore W4231067112C27081682 @default.
- W4231067112 hasConceptScore W4231067112C2775858608 @default.
- W4231067112 hasConceptScore W4231067112C2777602617 @default.
- W4231067112 hasConceptScore W4231067112C2777937089 @default.
- W4231067112 hasConceptScore W4231067112C2778186239 @default.
- W4231067112 hasConceptScore W4231067112C42219234 @default.
- W4231067112 hasConceptScore W4231067112C71924100 @default.
- W4231067112 hasConceptScore W4231067112C98274493 @default.
- W4231067112 hasIssue "5" @default.
- W4231067112 hasLocation W42310671121 @default.
- W4231067112 hasOpenAccess W4231067112 @default.
- W4231067112 hasPrimaryLocation W42310671121 @default.
- W4231067112 hasRelatedWork W1771027348 @default.
- W4231067112 hasRelatedWork W1970099699 @default.
- W4231067112 hasRelatedWork W2004642498 @default.
- W4231067112 hasRelatedWork W2016925898 @default.
- W4231067112 hasRelatedWork W2052686354 @default.
- W4231067112 hasRelatedWork W2084439527 @default.
- W4231067112 hasRelatedWork W2120557693 @default.
- W4231067112 hasRelatedWork W2476525885 @default.
- W4231067112 hasRelatedWork W2736917669 @default.
- W4231067112 hasRelatedWork W2174961586 @default.
- W4231067112 hasVolume "199" @default.
- W4231067112 isParatext "false" @default.
- W4231067112 isRetracted "false" @default.
- W4231067112 workType "article" @default.