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- W4231079077 abstract "(Neuron 53, 337–351; February 1, 2007) In Figure 7 on page 345, the image in panel (E) (6-month-old nTg) is repeated in panel (F) instead of showing 1-month-old PS19. Figure 7F should have been replaced by the version shown below.Figure 7FView Large Image Figure ViewerDownload Hi-res image Download (PPT) Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse ModelYoshiyama et al.NeuronFebruary 01, 2007In BriefFilamentous tau inclusions are hallmarks of Alzheimer's disease (AD) and related tauopathies, but earlier pathologies may herald disease onset. To investigate this, we studied wild-type and P301S mutant human tau transgenic (Tg) mice. Filamentous tau lesions developed in P301S Tg mice at 6 months of age, and progressively accumulated in association with striking neuron loss as well as hippocampal and entorhinal cortical atrophy by 9-12 months of age. Remarkably, hippocampal synapse loss and impaired synaptic function were detected in 3 month old P301S Tg mice before fibrillary tau tangles emerged. Full-Text PDF Open Archive" @default.
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- W4231079077 date "2007-04-01" @default.
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- W4231079077 title "Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model" @default.
- W4231079077 doi "https://doi.org/10.1016/j.neuron.2007.03.022" @default.
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