Matches in SemOpenAlex for { <https://semopenalex.org/work/W4231228400> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4231228400 abstract "Diarthrodial joints possess an extensive network of sensory and sympathetic nerve fibres whose physiological functions are varied and complex. Nerves are primarily located in the synovium but also innervate the subchondral bone, the outer third of menisci, and the superficial surface of tendons and ligaments. Large-diameter, myelinated neurons are involved in joint position sense while small-diameter neurons with thin or no myelin typically sense pain. The small-diameter nerves in conjunction with sympathetic fibres control synovial blood flow and maintain joint homeostasis. In patients with osteoarthritis (OA), the sensory nerves become sensitized and increase their firing rate in response to normal movement. This peripheral sensitization is mediated by numerous algogenic agents released into the OA knee including neuropeptides, eicosanoids, and proteinases. A portion of joint afferents fire in the absence of mechanical stimuli and encode pain at rest. Interestingly, the firing rate of joint afferents does not correlate with OA severity, indicating that pain is a poor predictor of joint pathology. Evidence is accumulating to suggest that a subpopulation of OA patients who are unresponsive to classical non-steroidal anti-inflammatory drugs may be suffering from neuropathic pain in which there is damage to the joint nerves themselves. Better understanding of the biology of joint nerves could help in the development of patient-targeted therapies to alleviate OA pain and inflammation." @default.
- W4231228400 created "2022-05-12" @default.
- W4231228400 creator A5004167898 @default.
- W4231228400 creator A5043090859 @default.
- W4231228400 date "2016-11-01" @default.
- W4231228400 modified "2023-09-23" @default.
- W4231228400 title "The innervation of the joint and its role in osteoarthritis pain" @default.
- W4231228400 doi "https://doi.org/10.1093/med/9780199668847.003.0007" @default.
- W4231228400 hasPublicationYear "2016" @default.
- W4231228400 type Work @default.
- W4231228400 citedByCount "0" @default.
- W4231228400 crossrefType "book" @default.
- W4231228400 hasAuthorship W4231228400A5004167898 @default.
- W4231228400 hasAuthorship W4231228400A5043090859 @default.
- W4231228400 hasConcept C126322002 @default.
- W4231228400 hasConcept C141071460 @default.
- W4231228400 hasConcept C142724271 @default.
- W4231228400 hasConcept C15490471 @default.
- W4231228400 hasConcept C15744967 @default.
- W4231228400 hasConcept C169760540 @default.
- W4231228400 hasConcept C170493617 @default.
- W4231228400 hasConcept C172659308 @default.
- W4231228400 hasConcept C203014093 @default.
- W4231228400 hasConcept C204787440 @default.
- W4231228400 hasConcept C2776164576 @default.
- W4231228400 hasConcept C2776217527 @default.
- W4231228400 hasConcept C2776237595 @default.
- W4231228400 hasConcept C2776914184 @default.
- W4231228400 hasConcept C2779663596 @default.
- W4231228400 hasConcept C2908736133 @default.
- W4231228400 hasConcept C3020332539 @default.
- W4231228400 hasConcept C46762472 @default.
- W4231228400 hasConcept C71924100 @default.
- W4231228400 hasConcept C94487597 @default.
- W4231228400 hasConceptScore W4231228400C126322002 @default.
- W4231228400 hasConceptScore W4231228400C141071460 @default.
- W4231228400 hasConceptScore W4231228400C142724271 @default.
- W4231228400 hasConceptScore W4231228400C15490471 @default.
- W4231228400 hasConceptScore W4231228400C15744967 @default.
- W4231228400 hasConceptScore W4231228400C169760540 @default.
- W4231228400 hasConceptScore W4231228400C170493617 @default.
- W4231228400 hasConceptScore W4231228400C172659308 @default.
- W4231228400 hasConceptScore W4231228400C203014093 @default.
- W4231228400 hasConceptScore W4231228400C204787440 @default.
- W4231228400 hasConceptScore W4231228400C2776164576 @default.
- W4231228400 hasConceptScore W4231228400C2776217527 @default.
- W4231228400 hasConceptScore W4231228400C2776237595 @default.
- W4231228400 hasConceptScore W4231228400C2776914184 @default.
- W4231228400 hasConceptScore W4231228400C2779663596 @default.
- W4231228400 hasConceptScore W4231228400C2908736133 @default.
- W4231228400 hasConceptScore W4231228400C3020332539 @default.
- W4231228400 hasConceptScore W4231228400C46762472 @default.
- W4231228400 hasConceptScore W4231228400C71924100 @default.
- W4231228400 hasConceptScore W4231228400C94487597 @default.
- W4231228400 hasLocation W42312284001 @default.
- W4231228400 hasOpenAccess W4231228400 @default.
- W4231228400 hasPrimaryLocation W42312284001 @default.
- W4231228400 hasRelatedWork W12390499 @default.
- W4231228400 hasRelatedWork W13251716 @default.
- W4231228400 hasRelatedWork W15396697 @default.
- W4231228400 hasRelatedWork W16812718 @default.
- W4231228400 hasRelatedWork W19310651 @default.
- W4231228400 hasRelatedWork W2140798 @default.
- W4231228400 hasRelatedWork W26081035 @default.
- W4231228400 hasRelatedWork W3246272 @default.
- W4231228400 hasRelatedWork W4652545 @default.
- W4231228400 hasRelatedWork W5250891 @default.
- W4231228400 isParatext "false" @default.
- W4231228400 isRetracted "false" @default.
- W4231228400 workType "book" @default.