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- W4231273969 abstract "MicroRNAs (miRNAs) are endogenous noncoding RNAs that regulate various biological processes. miR-125b is a miRNA that has been reported to be critical for hair follicle (HF) morphogenesis and development. We identified that the expression of miR-125b varies during an individual hair cycle (anagen, catagen, and telogen) in the skin of cashmere goats. We constructed a gain model (by overexpressing miR-125b) and a loss model (by inhibiting endogenous miR-125b) based on dermal papilla cells (DPCs) to further investigate the role of miR-125b in HF cycle. In addition, we used a dual-luciferase system to highlight the predicated target genes of miR-125b. We found that miR-125b affects the expression of FGF5, IGF-1, SHH, TNF-α, MSX2, LEF-1, FGF7, NOGGIN, BMP2, BMP4, TGF-β1, and β-catenin. The dual-luciferase assay further validated a direct interaction between miR-125b and FGF5 and TNF-α. miR-125b affects the expression levels of genes related to hair cycle and may also play a critical role in regulating the periodic development of HF." @default.
- W4231273969 created "2022-05-12" @default.
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- W4231273969 date "2017-01-01" @default.
- W4231273969 modified "2023-10-16" @default.
- W4231273969 title "Effect of miR-125b on dermal papilla cells of goat secondary hair follicle" @default.
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- W4231273969 doi "https://doi.org/10.1016/j.ejbt.2016.11.006" @default.
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