FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4231276648> ?p ?o ?g. }

• W4231276648 endingPage "84" @default.
• W4231276648 startingPage "79" @default.
• W4231276648 abstract "Abstract: Pretreatment with nitric oxide synthase (NOS) inhibitors profoundly increases mortality, bacterial burden and pathological tissue damage in mice infected with Mycobacterium tuberculosis . Nitric oxide (NO) production is enhanced in alveolar macrophages (AM) of tuberculosis (TB) patients. Interleukin (IL)‐1β and tumour necrosis factor (TNF)‐α released from AM are involved in the immune response to mycobacterial infection. The aim of the present study was to examine whether NO is implicated in IL‐1β and TNF‐α synthesis by AM and related to the resolution of disease activity in TB patients. Purified AM were retrieved by bronchoalveolar lavage from TB patients and normal subjects, and cultured in the presence or absence of a NO inhibitor, N G ‐monomethyl‐ L ‐arginine ( L ‐NMMA). The release of IL‐1β and TNF‐α, and their mRNA expression were determined by enzyme‐linked immunosorbent assay (ELISA) and northern analysis, respectively. The level of nitrite released into the culture medium was determined. The rate of disease regression was evaluated by serial chest radiography. The release of nitrite, IL‐1β and TNF‐α was much greater from AM of TB patients than normal subjects. N G ‐monomethyl‐ L ‐arginine inhibited the production of nitrite as well as IL‐1β and TNF‐α in TB patients. The mRNA expression for IL‐1β and TNF‐α was upregulated in TB patients and was depressed by L ‐NMMA. Immunocytochemistry using a monoclonal antibody against nuclear factor‐κB (NF‐κB) subunit p65 showed NF‐κB was highly expressed and translocated to the nuclei of AM in TB patients, and was inhibited by L ‐NMMA. An inhibition of NF‐κB by pyrrolidine dithiocarbamate attenuated IL‐1β and TNF‐α synthesis. More generation of NO from cultured AM increased the disease regression in TB patients. We conclude that the enhanced NO generation by AM of TB patients may play an autoregulatory role in amplifying the synthesis of pro‐inflammatory cytokines, probably through the activation of NF‐κB. Nitric oxide may also play an important role in resistance to M. tuberculosis infection." @default.
• W4231276648 created "2022-05-12" @default.
• W4231276648 creator A5025024898 @default.
• W4231276648 creator A5063470346 @default.
• W4231276648 date "2001-03-01" @default.
• W4231276648 modified "2023-10-16" @default.
• W4231276648 title "Nitric oxide modulates interleukin‐1β and tumour necrosis factor‐α synthesis, and disease regression by alveolar macrophages in pulmonary tuberculosis" @default.
• W4231276648 cites W1516830966 @default.
• W4231276648 cites W1532427044 @default.
• W4231276648 cites W1583712812 @default.
• W4231276648 cites W1963492254 @default.
• W4231276648 cites W2003281598 @default.
• W4231276648 cites W2011185588 @default.
• W4231276648 cites W2013985149 @default.
• W4231276648 cites W2028501194 @default.
• W4231276648 cites W2048597976 @default.
• W4231276648 cites W2061256473 @default.
• W4231276648 cites W2081620188 @default.
• W4231276648 cites W2085837280 @default.
• W4231276648 cites W2089199666 @default.
• W4231276648 cites W2100219870 @default.
• W4231276648 cites W2109515608 @default.
• W4231276648 cites W2114220827 @default.
• W4231276648 cites W2117667204 @default.
• W4231276648 cites W2131265202 @default.
• W4231276648 cites W2142541950 @default.
• W4231276648 cites W2151892297 @default.
• W4231276648 doi "https://doi.org/10.1111/j.1440-1843.2001.00302.x" @default.
• W4231276648 hasPublicationYear "2001" @default.
• W4231276648 type Work @default.
• W4231276648 citedByCount "1" @default.
• W4231276648 crossrefType "journal-article" @default.
• W4231276648 hasAuthorship W4231276648A5025024898 @default.
• W4231276648 hasAuthorship W4231276648A5063470346 @default.
• W4231276648 hasConcept C126322002 @default.
• W4231276648 hasConcept C142724271 @default.
• W4231276648 hasConcept C17991360 @default.
• W4231276648 hasConcept C18903297 @default.
• W4231276648 hasConcept C203014093 @default.
• W4231276648 hasConcept C2776178081 @default.
• W4231276648 hasConcept C2776179834 @default.
• W4231276648 hasConcept C2776384668 @default.
• W4231276648 hasConcept C2777622882 @default.
• W4231276648 hasConcept C2777714996 @default.
• W4231276648 hasConcept C2777961210 @default.
• W4231276648 hasConcept C2777975735 @default.
• W4231276648 hasConcept C2778543330 @default.
• W4231276648 hasConcept C2781069245 @default.
• W4231276648 hasConcept C2908937200 @default.
• W4231276648 hasConcept C503630168 @default.
• W4231276648 hasConcept C519581460 @default.
• W4231276648 hasConcept C71924100 @default.
• W4231276648 hasConcept C86803240 @default.
• W4231276648 hasConceptScore W4231276648C126322002 @default.
• W4231276648 hasConceptScore W4231276648C142724271 @default.
• W4231276648 hasConceptScore W4231276648C17991360 @default.
• W4231276648 hasConceptScore W4231276648C18903297 @default.
• W4231276648 hasConceptScore W4231276648C203014093 @default.
• W4231276648 hasConceptScore W4231276648C2776178081 @default.
• W4231276648 hasConceptScore W4231276648C2776179834 @default.
• W4231276648 hasConceptScore W4231276648C2776384668 @default.
• W4231276648 hasConceptScore W4231276648C2777622882 @default.
• W4231276648 hasConceptScore W4231276648C2777714996 @default.
• W4231276648 hasConceptScore W4231276648C2777961210 @default.
• W4231276648 hasConceptScore W4231276648C2777975735 @default.
• W4231276648 hasConceptScore W4231276648C2778543330 @default.
• W4231276648 hasConceptScore W4231276648C2781069245 @default.
• W4231276648 hasConceptScore W4231276648C2908937200 @default.
• W4231276648 hasConceptScore W4231276648C503630168 @default.
• W4231276648 hasConceptScore W4231276648C519581460 @default.
• W4231276648 hasConceptScore W4231276648C71924100 @default.
• W4231276648 hasConceptScore W4231276648C86803240 @default.
• W4231276648 hasIssue "1" @default.
• W4231276648 hasLocation W42312766481 @default.
• W4231276648 hasOpenAccess W4231276648 @default.
• W4231276648 hasPrimaryLocation W42312766481 @default.
• W4231276648 hasRelatedWork W1972194921 @default.
• W4231276648 hasRelatedWork W1985900017 @default.
• W4231276648 hasRelatedWork W2122830164 @default.
• W4231276648 hasRelatedWork W2234525213 @default.
• W4231276648 hasRelatedWork W2349894740 @default.
• W4231276648 hasRelatedWork W2415133252 @default.
• W4231276648 hasRelatedWork W2788398649 @default.
• W4231276648 hasRelatedWork W4232735058 @default.
• W4231276648 hasRelatedWork W4377940992 @default.
• W4231276648 hasRelatedWork W2108732647 @default.
• W4231276648 hasVolume "6" @default.
• W4231276648 isParatext "false" @default.
• W4231276648 isRetracted "false" @default.
• W4231276648 workType "article" @default.