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- W4231344314 abstract "Click to increase image sizeClick to decrease image sizeThe research criteria of treatment resistance in schizophrenia are reviewed and discussed, and a definition for the use in the clinic is proposed. The article also reviews efficacy studies and the recommendation for the psychopharmacologic treatment of therapy-resistant schizophrenia. Placebo-controlled and open trials have shown clozapine to be clearly effective in 30–60% of patients resistant to conventional antipsychotic treatment. Clozapine has been found to reduce positive and negative symptoms and to enhance both cognitive and psychosocial function in schizophrenics. Some schizophrenics cannot be treated with clozapine because of contraindications or do not respond sufficiently. In these patients conventional antipsychotics have to be prescribed and augmented with benzodiazepines, antidepressants, lithium, anticonvulsants, or electroconvulsive treatment.ClozapinePharmacologic treatmentTreatment augmentationTreatment-resistant schizophrenia" @default.
- W4231344314 created "2022-05-12" @default.
- W4231344314 creator A5025353819 @default.
- W4231344314 date "1998-01-01" @default.
- W4231344314 modified "2023-10-18" @default.
- W4231344314 title "Behandlingsresistent skizofreni" @default.
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- W4231344314 doi "https://doi.org/10.1080/08039488.1998.11884448" @default.
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