Matches in SemOpenAlex for { <https://semopenalex.org/work/W4231375204> ?p ?o ?g. }
Showing items 1 to 51 of
51
with 100 items per page.
- W4231375204 abstract "FTY720 is a treatment for relapsing remitting multiple sclerosis (MS). It is an analog of sphingosine-1-phosphate (S1P) and targets S1P receptors 1, 3, 4, and 5. Recent reports indicate an association between long-term exposure to FTY720 and cases of cryptococcal infection. Here, we studied the effect of FTY720 and its derivative, BAF312, which only target S1P receptors 1 and 5, in a mouse model of cryptococcal infection. We found that treatment with FTY720, but not with BAF312, led to decreased survival and increased organ burden in mouse cryptococcal granulomas. Both FTY720 and BAF312 caused a profound CD4+ and CD8+ T cell depletion in blood and lungs but only treatment with FTY720 led to cryptococcal reactivation. Treatment with FTY720, but not with BAF312, was associated with disorganization of macrophages and with M2 polarization at the granuloma site. In a cell system, FTY720 decreased phagocytosis and production of reactive oxygen species by macrophages, a phenotype recapitulated in the S1pr3-/- knockout macrophages. Our results suggest that FTY720 reactivates cryptococcosis from the granuloma through a S1P receptor 3-mediated mechanism and support the rationale for development of more-specific receptor modulators for therapeutic use of MS. PMID: 32484801 Funding information This work was supported by: NIAID NIH HHS, United States Grant ID: R01 AI136934 NIAID NIH HHS, United States Grant ID: R01 AI125770 NIAID NIH HHS, United States Grant ID: R01 AI116420 BLRD VA, United States Grant ID: I01 BX002624" @default.
- W4231375204 created "2022-05-12" @default.
- W4231375204 creator A5022799608 @default.
- W4231375204 date "2020-12-06" @default.
- W4231375204 modified "2023-09-26" @default.
- W4231375204 title "Faculty Opinions recommendation of FTY720 reactivates cryptococcal granulomas in mice through S1P receptor 3 on macrophages." @default.
- W4231375204 doi "https://doi.org/10.3410/f.738066999.793580816" @default.
- W4231375204 hasPublicationYear "2020" @default.
- W4231375204 type Work @default.
- W4231375204 citedByCount "0" @default.
- W4231375204 crossrefType "dataset" @default.
- W4231375204 hasAuthorship W4231375204A5022799608 @default.
- W4231375204 hasBestOaLocation W42313752041 @default.
- W4231375204 hasConcept C126322002 @default.
- W4231375204 hasConcept C160448771 @default.
- W4231375204 hasConcept C167672396 @default.
- W4231375204 hasConcept C170493617 @default.
- W4231375204 hasConcept C182704531 @default.
- W4231375204 hasConcept C203014093 @default.
- W4231375204 hasConcept C2776596873 @default.
- W4231375204 hasConcept C2778703144 @default.
- W4231375204 hasConcept C2779413141 @default.
- W4231375204 hasConcept C71924100 @default.
- W4231375204 hasConcept C8891405 @default.
- W4231375204 hasConceptScore W4231375204C126322002 @default.
- W4231375204 hasConceptScore W4231375204C160448771 @default.
- W4231375204 hasConceptScore W4231375204C167672396 @default.
- W4231375204 hasConceptScore W4231375204C170493617 @default.
- W4231375204 hasConceptScore W4231375204C182704531 @default.
- W4231375204 hasConceptScore W4231375204C203014093 @default.
- W4231375204 hasConceptScore W4231375204C2776596873 @default.
- W4231375204 hasConceptScore W4231375204C2778703144 @default.
- W4231375204 hasConceptScore W4231375204C2779413141 @default.
- W4231375204 hasConceptScore W4231375204C71924100 @default.
- W4231375204 hasConceptScore W4231375204C8891405 @default.
- W4231375204 hasLocation W42313752041 @default.
- W4231375204 hasOpenAccess W4231375204 @default.
- W4231375204 hasPrimaryLocation W42313752041 @default.
- W4231375204 hasRelatedWork W1959967360 @default.
- W4231375204 hasRelatedWork W1993414228 @default.
- W4231375204 hasRelatedWork W2057381927 @default.
- W4231375204 hasRelatedWork W2061457959 @default.
- W4231375204 hasRelatedWork W2137891075 @default.
- W4231375204 hasRelatedWork W2139873095 @default.
- W4231375204 hasRelatedWork W2144812225 @default.
- W4231375204 hasRelatedWork W2401099396 @default.
- W4231375204 hasRelatedWork W2410207023 @default.
- W4231375204 hasRelatedWork W2437860659 @default.
- W4231375204 isParatext "false" @default.
- W4231375204 isRetracted "false" @default.
- W4231375204 workType "dataset" @default.