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• W4231607387 abstract "To evaluate if there are differences regarding disease location and mortality of necrotizing enterocolitis, according to the gestational age at birth, in newborns submitted to surgery due to enterocolite. A historical cohort study of 198 newborns submitted to surgery due to necrotizing enterecolitis in a tertiary hospital, from November 1991 to December 2012. The newborns were divided into different categories according to gestational age (<30 weeks, 30–33 weeks and 6 days, 34–36 weeks and 6 days, and ≥37 weeks), and were followed for 60 days after surgery. The inclusion criterion was the presence of histological findings of necrotizing enterocolitis in the pathology. Patients with single intestinal perforation were excluded. The jejunum was the most commonly affected site in extremely premature infants (p = 0.01), whereas the ileum was the most commonly affected site in premature infants (p = 0.002), and the colon in infants born at term (p < 0.001). With the increasing gestational age, it was observed that intestinal involvement decreased for the ileum and the jejunum (decreasing from 45% to 0% and from 5% to 0%, respectively), with a progressive increase in colon involvement (0% to 84%). Total mortality rate was 45.5%, and no statistical difference was observed in the mortality at different gestational ages (p = 0.287). In newborns submitted to surgery due to necrotizing enterocolitis, the disease in extremely preterm infants was more common in the jejunum, whereas in preterm infants, the most affected site was the ileum, and in newborns born close to term, it was the colon. No difference in mortality was observed according to the gestational age at birth. Avaliar se há diferença de localização e de mortalidade da enterocolite necrosante de acordo com a idade gestacional ao nascimento, em neonatos operados por enterocolite. Coorte histórica de 198 neonatos operados por enterocolite necrosante em hospital terciário, de novembro de 1991 a dezembro de 2012. Os recém‐nascidos operados foram divididos em diferentes categorias de acordo com a idade gestacional (< 30 semanas, 30 a 33 semanas e seis dias, 34 a 36 semanas e seis dias e ≥ 37 semanas) e foram seguidos por 60 dias depois da cirurgia. O critério de inclusão foi a presença de achados histológicos de enterocolite necrosante no anatomopatológico e o de exclusão foi a presença de perfuração intestinal única. O jejuno foi mais acometido pela ECN nos prematuros extremos (p = 0,01); o íleo mais afetado nos recém‐nascidos prematuros (p = 0,002) e o cólon nos recém‐nascidos a termo ou próximos ao termo (p < 0,001). Com o aumento da idade gestacional, observam‐se redução do acometimento do jejuno e do íleo (regrediu de 45% para 0% e de 5% para 0%, respectivamente) e aumento progressivo do acometimento do cólon (0% para 84%). A mortalidade total das crianças operadas por ECN foi de 45,5%; não existiu diferença estatística na mortalidade nas diferentes idades gestacionais (p = 0,287). Em recém‐nascidos operados por enterocolite necrosante, a doença no jejuno foi mais comum no prematuro extremo, no íleo no prematuro, e a doença no cólon nos recém‐nascidos próximos ao termo. Não foi observada diferença de mortalidade de acordo com a idade gestacional ao nascimento." @default.
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• W4231607387 date "2018-05-01" @default.
• W4231607387 modified "2023-10-18" @default.
• W4231607387 title "There is an association between disease location and gestational age at birth in newborns submitted to surgery due to necrotizing enterocolitis" @default.
• W4231607387 doi "https://doi.org/10.1016/j.jpedp.2017.09.013" @default.
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