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- W4231684200 abstract "The purpose of this study was to characterize and evaluate the citotoxicity and antimicrobial activity of γaminobutiric acid-silica/tetracycline network thin films prepared by Matrix Assisted Pulsed Laser Evaporation (MAPLE). Thin films were characterized by Infrared Microscopy (IRM), X-ray Diffraction (XRD), Transmision Electron Microscopy (TEM) and Scanning Electron Microscopy (SEM). TEM images showed an average size of gammaaminobutiric acid-silica network (γ-AA/SiO2) lower than 10 nm. Unlike the dropcast samples, IRM recorded on MAPLE films revealed a good distribution of monitored functional groups on the entire scanned surface. Besides a good homogeneity of the coatings, SEM analysis revealed aggregates typical for MAPLE deposition, randomly distributed on the surface with an average diameter of ~300 nm. The biological evaluation of MAPLE nanobiocoated surfaces evidenced a good biocompatibility and an enhanced antibiofilm effect against both Gram positive (Staphylococcus aureus) and Gram negative (Escherichia coli) tested strains. Our results recommend the use of γ-aminobutiric acid-silica networks as matrixes for controlled local delivery of antibiotics, with practical applications in developing improved medical surfaces for the prevention or reduction of surface-associated microbial infections." @default.
- W4231684200 created "2022-05-12" @default.
- W4231684200 date "2014-12-10" @default.
- W4231684200 modified "2023-10-14" @default.
- W4231684200 title "Local delivery of tetracycline from γ-aminobutiric acid-silica networks thin films for preventing microbial colonization" @default.
- W4231684200 doi "https://doi.org/10.33263/bteb114.002009" @default.
- W4231684200 hasPublicationYear "2014" @default.
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