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• W4231686472 abstract "Abstract Clinical translation of nucleic acids drugs has been stunted by limited delivery options. Herein, we report a synthetic polymer designed to mimic viral mechanisms of delivery called VIPER (virus‐inspired polymer for endosomal release). VIPER is composed of a polycation block for condensation of nucleic acids, and a pH‐sensitive block for acid‐triggered display of a lytic peptide to promote trafficking to the cell cytosol. VIPER shows superior efficiencies compared to commercial agents when delivering genes to multiple immortalized cell lines. Importantly, in murine models, VIPER facilitates effective gene transfer to solid tumors." @default.
• W4231686472 created "2022-05-12" @default.
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• W4231686472 date "2016-08-19" @default.
• W4231686472 modified "2023-09-25" @default.
• W4231686472 title "Virus‐Inspired Polymer for Efficient In Vitro and In Vivo Gene Delivery" @default.
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• W4231686472 doi "https://doi.org/10.1002/ange.201605958" @default.
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