FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4231694619> ?p ?o ?g. }

• W4231694619 abstract "Background Gonadotropin‐releasing hormone (GnRH) antagonist protocols for pituitary down regulation in in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI) allow the use of GnRH agonists for triggering final oocyte maturation. Currently, human chorionic gonadotropin (HCG) is still the standard medication for this purpose. The effectiveness of triggering with a GnRH agonist compared to HCG measured as pregnancy and ovarian hyperstimulation(OHSS) rates are unknown. Objectives To compare the effectiveness of a GnRH agonist with HCG for triggering final oocyte maturation in IVF and ICSI patients undergoing controlled ovarian hyperstimulation in a GnRH antagonist protocol followed by embryo transfer. Search methods We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE , EMBASE, the National Research Register, the Medical Research Council's Clinical Trials Register, and the NHS Centre for Reviews and Dissemination database. We also examined the reference lists of all known primary studies and review articles, citation lists of relevant publications and abstracts of major scientific meetings. Selection criteria All randomised controlled studies (RCTs) reporting data comparing clinical outcomes for women undergoing IVF and ICSI cycles and using a GnRH agonist in comparison with HCG for final oocyte maturation triggering. Data collection and analysis Two review authors independently assessed trial quality and extracted data. Main results We identified 11 RCTs (n = 1055). Eight studies assessed fresh autologous cycles and three studies assessed donor‐recipient cycles. In fresh‐autologous cycles, GnRH agonist was less effective than HCG in terms of the live birth rate per randomised woman (OR 0.44, 95% CI 0.29 to 0.68; 4 RCTs) and ongoing pregnancy rate per randomised woman (OR 0.45, 95% CI 0.31 to 0.65; 8 RCTs). For a group with a 30% live birth or ongoing pregnancy rate using HCG, the rate would be between 12% and 22% using an GnRH agonist. Moderate to severe ovarian hyperstimulation syndrome (OHSS) incidence per randomised woman was significantly lower in the GnRH agonist group compared to the HCG group (OR 0.10, 95% CI 0.01 to 0.82; 5 RCTs). For a group with a 3% OHSS rate using HCG the rate would be between 0% and 2.6% using GnRH agonist. In donor recipient cycles, there was no evidence of a statistical difference in the live birth rate per randomised woman (OR 0.92, 95% CI 0.53 to 1.61; 1 RCT). Authors' conclusions We do not recommend that GnRH agonists be routinely used as a final oocyte maturation trigger in fresh autologous cycles because of lowered live birth rates and ongoing pregnancy rates. An exception could be made for women with high risk of OHSS, after appropriate counselling." @default.
• W4231694619 created "2022-05-12" @default.
• W4231694619 creator A5018646147 @default.
• W4231694619 creator A5025273145 @default.
• W4231694619 creator A5047756279 @default.
• W4231694619 creator A5049231598 @default.
• W4231694619 creator A5073182568 @default.
• W4231694619 creator A5086304795 @default.
• W4231694619 date "2010-11-10" @default.
• W4231694619 modified "2023-09-28" @default.
• W4231694619 title "Gonadotropin-releasing hormone agonist versus HCG for oocyte triggering in antagonist assisted reproductive technology cycles" @default.
• W4231694619 cites W141627978 @default.
• W4231694619 cites W1598602811 @default.
• W4231694619 cites W1607039864 @default.
• W4231694619 cites W1862454656 @default.
• W4231694619 cites W1898915641 @default.
• W4231694619 cites W195800306 @default.
• W4231694619 cites W1964913259 @default.
• W4231694619 cites W1965768870 @default.
• W4231694619 cites W1969697368 @default.
• W4231694619 cites W1972018407 @default.
• W4231694619 cites W1985168254 @default.
• W4231694619 cites W1987404568 @default.
• W4231694619 cites W1996215930 @default.
• W4231694619 cites W2010122175 @default.
• W4231694619 cites W2018081588 @default.
• W4231694619 cites W2021584960 @default.
• W4231694619 cites W2022003509 @default.
• W4231694619 cites W2023128435 @default.
• W4231694619 cites W2024186224 @default.
• W4231694619 cites W2028513675 @default.
• W4231694619 cites W2029108385 @default.
• W4231694619 cites W2037420362 @default.
• W4231694619 cites W2038762120 @default.
• W4231694619 cites W2040206122 @default.
• W4231694619 cites W2040415486 @default.
• W4231694619 cites W2046371428 @default.
• W4231694619 cites W2057182107 @default.
• W4231694619 cites W2066688325 @default.
• W4231694619 cites W2069020222 @default.
• W4231694619 cites W2070512684 @default.
• W4231694619 cites W2084147157 @default.
• W4231694619 cites W2085998115 @default.
• W4231694619 cites W2108513996 @default.
• W4231694619 cites W2116581812 @default.
• W4231694619 cites W2121095266 @default.
• W4231694619 cites W2132220665 @default.
• W4231694619 cites W2132685181 @default.
• W4231694619 cites W2134043108 @default.
• W4231694619 cites W2141385816 @default.
• W4231694619 cites W2141957584 @default.
• W4231694619 cites W2144134737 @default.
• W4231694619 cites W2150107992 @default.
• W4231694619 cites W2151670872 @default.
• W4231694619 cites W2151991044 @default.
• W4231694619 cites W2153711259 @default.
• W4231694619 cites W2155645913 @default.
• W4231694619 cites W2158911427 @default.
• W4231694619 cites W2159529998 @default.
• W4231694619 cites W2166149561 @default.
• W4231694619 cites W2343971792 @default.
• W4231694619 cites W2405128650 @default.
• W4231694619 cites W2414082353 @default.
• W4231694619 cites W4231937295 @default.
• W4231694619 doi "https://doi.org/10.1002/14651858.cd008046.pub2" @default.
• W4231694619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21069701" @default.
• W4231694619 hasPublicationYear "2010" @default.
• W4231694619 type Work @default.
• W4231694619 citedByCount "15" @default.
• W4231694619 countsByYear W42316946192014 @default.
• W4231694619 countsByYear W42316946192015 @default.
• W4231694619 countsByYear W42316946192016 @default.
• W4231694619 countsByYear W42316946192017 @default.
• W4231694619 countsByYear W42316946192019 @default.
• W4231694619 countsByYear W42316946192021 @default.
• W4231694619 countsByYear W42316946192023 @default.
• W4231694619 crossrefType "reference-entry" @default.
• W4231694619 hasAuthorship W4231694619A5018646147 @default.
• W4231694619 hasAuthorship W4231694619A5025273145 @default.
• W4231694619 hasAuthorship W4231694619A5047756279 @default.
• W4231694619 hasAuthorship W4231694619A5049231598 @default.
• W4231694619 hasAuthorship W4231694619A5073182568 @default.
• W4231694619 hasAuthorship W4231694619A5086304795 @default.
• W4231694619 hasConcept C126322002 @default.
• W4231694619 hasConcept C160099875 @default.
• W4231694619 hasConcept C16685009 @default.
• W4231694619 hasConcept C170493617 @default.
• W4231694619 hasConcept C2775948956 @default.
• W4231694619 hasConcept C2776537878 @default.
• W4231694619 hasConcept C2777886879 @default.
• W4231694619 hasConcept C2778278907 @default.
• W4231694619 hasConcept C2778279030 @default.
• W4231694619 hasConcept C2778478619 @default.
• W4231694619 hasConcept C2778575703 @default.
• W4231694619 hasConcept C2778894405 @default.
• W4231694619 hasConcept C2778938600 @default.
• W4231694619 hasConcept C2779192864 @default.
• W4231694619 hasConcept C2779234561 @default.
• W4231694619 hasConcept C2781065240 @default.
• W4231694619 hasConcept C29456083 @default.

• next