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- W4231716052 abstract "Purpose Age-related macular degeneration is the most common cause of blindness in the western world among elderly people. In response to anti-VEGF treatment for wet-AMD retinal anatomy and visual acuity is often remedied. In our previous study, we showed that also visual evoked potentials (VEP) improve following successful anti-VEGF treatment. The aim of the present study was to investigate, if visual acuity and retinal thickness changes are associated with VEP parameters. Methods Fifteen patients enrolled this study. Patients received three bevacizumab intravitreal injections. At the beginning of the study and 4-6 weeks after the last injection, the best corrected visual acuity (BCVA) test, full biomicroscope examination, OCT analysis and VEP were performed. Results In treated eyes, logMAR visual acuity decreased on average 0.2±0.3 units, OCT retinal thickness decreased 170±200 micrometers and VEP amplitude increased 1.0±1.4 microvolts. All changes were significant at p<0.05. The relative changes of VEP amplitude and retinal thickness correlated significantly r=-0.630 (p<0.05), as well visual acuity (logMAR) and retinal thickness r=0.576 (p<0.05). VEP latency did not correlate with retinal thickness or visual acuity. Conclusion We showed that both the increase in VEP amplitude and the improvement in visual acuity are correlated with the decrease in retinal thickness in treated wet-AMD patients indicating that successful intravitreal anti-VEGF treatment initiates significant changes in upstream visual processing in the brain." @default.
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- W4231716052 date "2014-08-20" @default.
- W4231716052 modified "2023-09-26" @default.
- W4231716052 title "The best corrected visual acuity and retinal thickness are associated with improved cortical visual processing in treated wet-AMD patients" @default.
- W4231716052 doi "https://doi.org/10.1111/j.1755-3768.2014.1676.x" @default.
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