Matches in SemOpenAlex for { <https://semopenalex.org/work/W4231772685> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W4231772685 endingPage "760" @default.
- W4231772685 startingPage "755" @default.
- W4231772685 abstract "The purpose of this study was to estimate striatal dopamine (D2) receptor availability in non-drug treated children with attention-deficit-hyperactivity disorder (ADHD) before and after methylphenidate therapy, and to examine correlations between severity of symptoms and response rates to stimulant medication with levels of striatal D2 receptor binding. Nine children (six males, three females; mean age 9.8 years, SD 2.3 years) with ADHD participated. All underwent iodobenzamide (123I IBZM) brain SPECT within 2 hours following intravenous injection of 123I IBZM before and 3 months after methylphenidate therapy. A semiquantitative approach was used to generate indices of specific D2 receptor binding in the basal ganglia. Specific binding ratios at baseline were higher than the previously reported specific binding values obtained in studies using young healthy adults. D2 availability reduced significantly (paired t-test, p<0.05) as a function of methylphenidate therapy in patients with ADHD in all four regions of the striatum. When the relation between therapy response and D2 availability was investigated, we observed that the higher the baseline D2 levels were, the higher the response rate was (detected as the percentage reduction of hyperactivity scores and Conners Teacher Rating Scale scores), while no such trend was observed between the initial D2 binding levels and the response in attention-deficit scores. Results indicate that in non-drug treated children with ADHD, higher D2 receptor availability is observed at baseline which is down-regulated back to reported near-normal values after methylphenidate therapy. The effect of methylphenidate on D2 receptor levels in patients with ADHD is similar to that observed in healthy adults; a down-regulation phenomenon within 0 to 30%. In addition, initially higher values of D2 availability seem to indicate better response to methylphenidate therapy in ADHD." @default.
- W4231772685 created "2022-05-12" @default.
- W4231772685 creator A5009343002 @default.
- W4231772685 creator A5046019717 @default.
- W4231772685 creator A5058817820 @default.
- W4231772685 creator A5064329383 @default.
- W4231772685 creator A5069668267 @default.
- W4231772685 creator A5077345410 @default.
- W4231772685 date "2007-02-13" @default.
- W4231772685 modified "2023-10-15" @default.
- W4231772685 title "Is increased D2 receptor availability associated with response to stimulant medication in ADHD" @default.
- W4231772685 cites W171691018 @default.
- W4231772685 cites W1964767493 @default.
- W4231772685 cites W1977634040 @default.
- W4231772685 cites W1996022014 @default.
- W4231772685 cites W2005503125 @default.
- W4231772685 cites W2006715508 @default.
- W4231772685 cites W2007894396 @default.
- W4231772685 cites W2014974452 @default.
- W4231772685 cites W2019058368 @default.
- W4231772685 cites W2040289365 @default.
- W4231772685 cites W2050256256 @default.
- W4231772685 cites W2050499198 @default.
- W4231772685 cites W2057856982 @default.
- W4231772685 cites W2062525876 @default.
- W4231772685 cites W2064351844 @default.
- W4231772685 cites W2064396657 @default.
- W4231772685 cites W2082745607 @default.
- W4231772685 cites W2097559385 @default.
- W4231772685 cites W2107173687 @default.
- W4231772685 cites W2112098409 @default.
- W4231772685 cites W2139591064 @default.
- W4231772685 cites W2148955566 @default.
- W4231772685 cites W2166592825 @default.
- W4231772685 cites W2417506438 @default.
- W4231772685 cites W2917847653 @default.
- W4231772685 doi "https://doi.org/10.1111/j.1469-8749.2001.tb00157.x" @default.
- W4231772685 hasPublicationYear "2007" @default.
- W4231772685 type Work @default.
- W4231772685 citedByCount "0" @default.
- W4231772685 crossrefType "journal-article" @default.
- W4231772685 hasAuthorship W4231772685A5009343002 @default.
- W4231772685 hasAuthorship W4231772685A5046019717 @default.
- W4231772685 hasAuthorship W4231772685A5058817820 @default.
- W4231772685 hasAuthorship W4231772685A5064329383 @default.
- W4231772685 hasAuthorship W4231772685A5069668267 @default.
- W4231772685 hasAuthorship W4231772685A5077345410 @default.
- W4231772685 hasConcept C118552586 @default.
- W4231772685 hasConcept C126322002 @default.
- W4231772685 hasConcept C15744967 @default.
- W4231772685 hasConcept C2777112843 @default.
- W4231772685 hasConcept C2778024521 @default.
- W4231772685 hasConcept C2778187257 @default.
- W4231772685 hasConcept C2779306644 @default.
- W4231772685 hasConcept C2780062018 @default.
- W4231772685 hasConcept C2780557958 @default.
- W4231772685 hasConcept C2780783007 @default.
- W4231772685 hasConcept C44208683 @default.
- W4231772685 hasConcept C513476851 @default.
- W4231772685 hasConcept C529278444 @default.
- W4231772685 hasConcept C71924100 @default.
- W4231772685 hasConceptScore W4231772685C118552586 @default.
- W4231772685 hasConceptScore W4231772685C126322002 @default.
- W4231772685 hasConceptScore W4231772685C15744967 @default.
- W4231772685 hasConceptScore W4231772685C2777112843 @default.
- W4231772685 hasConceptScore W4231772685C2778024521 @default.
- W4231772685 hasConceptScore W4231772685C2778187257 @default.
- W4231772685 hasConceptScore W4231772685C2779306644 @default.
- W4231772685 hasConceptScore W4231772685C2780062018 @default.
- W4231772685 hasConceptScore W4231772685C2780557958 @default.
- W4231772685 hasConceptScore W4231772685C2780783007 @default.
- W4231772685 hasConceptScore W4231772685C44208683 @default.
- W4231772685 hasConceptScore W4231772685C513476851 @default.
- W4231772685 hasConceptScore W4231772685C529278444 @default.
- W4231772685 hasConceptScore W4231772685C71924100 @default.
- W4231772685 hasIssue "11" @default.
- W4231772685 hasLocation W42317726851 @default.
- W4231772685 hasOpenAccess W4231772685 @default.
- W4231772685 hasPrimaryLocation W42317726851 @default.
- W4231772685 hasRelatedWork W1515293690 @default.
- W4231772685 hasRelatedWork W1694211331 @default.
- W4231772685 hasRelatedWork W1989270852 @default.
- W4231772685 hasRelatedWork W2054400098 @default.
- W4231772685 hasRelatedWork W2120731123 @default.
- W4231772685 hasRelatedWork W2151076373 @default.
- W4231772685 hasRelatedWork W2210183568 @default.
- W4231772685 hasRelatedWork W2307832784 @default.
- W4231772685 hasRelatedWork W2419113107 @default.
- W4231772685 hasRelatedWork W2426593116 @default.
- W4231772685 hasVolume "43" @default.
- W4231772685 isParatext "false" @default.
- W4231772685 isRetracted "false" @default.
- W4231772685 workType "article" @default.