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- W4231774420 abstract "In Brief Objective To evaluate the effect of 17β-estradiol (E2) on the ability of human neutrophils to produce nitric oxide (NO) and its effects on platelet activation. Methods The expression of neuronal nitric oxide synthase (nNOS) protein and the formation of NO by 17β-E2-incubated neutrophils from men were studied in vitro (ten male volunteers, no medical-surgical antecedents, aged 25–45 years). Platelet aggregometry and changes in cyclic guanosine monophospate (cGMP) levels were used to bio-assay the functionality of NO released from neutrophils. Results Incubation of neutrophils derived from men with physiologic concentrations of 17β-E2 (10−10 to 10−8 mol/L) enhanced the expression of nNOS protein. 17β-E2-incubated neutrophils also showed a significant increase in their ability to generate NO measured by the conversion of [3H]-L-arginine to [3H]-L-citrulline. Furthermore, 17β-E2-incubated neutrophils showed a greater ability to prevent adenosine diphosphate (ADP)-induced platelet activation. Moreover, increased levels of cGMP were found in the coincubation of platelets with 17β-E2-treated neutrophils. Conclusion These results suggest that 17β-E2 increases the ability of human neutrophils to produce NO and therefore may contribute to cardiovascular disease protection. Estrogen may contribute to cardiovascular disease protection by enhancing the release of nitric oxide in human neutrophils." @default.
- W4231774420 created "2022-05-12" @default.
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- W4231774420 date "2000-02-01" @default.
- W4231774420 modified "2023-09-25" @default.
- W4231774420 title "17 Beta-Estradiol–Stimulated Nitric Oxide Production by Neutrophils" @default.
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- W4231774420 doi "https://doi.org/10.1097/00006250-200002000-00022" @default.
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