Matches in SemOpenAlex for { <https://semopenalex.org/work/W4231781696> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4231781696 abstract "Abstract Background： HPV16 is the main cause of cervical cancer. In our study, we aimed to investigate the role of HPV mutants HPV16 E6-178G/E7-647G in the proliferation and apoptosis of cervical cancer C33A cells. Methods： Plasmids encoding the HPV16 E7 prototype (E7-647A)-GV144, E7 mutant (E7-647G)-GV144, HPV16 E6/E7 prototype (E6-178T/E7-647A)-GV144, and E6/E7 mutant (E6-178G/E7-647G)-GV144 were stably transfected into cervical cancer C33A cells. Western blot analysis, CCK8 proliferation assay, cell cloning assay and flow cytometry were used to detect the effects of the different polymorphism sites in HPV16 on cell proliferation and apoptosis. Results： HPV16 mutations promoted the proliferation and inhibited the apoptosis of cervical cancer C33A cells, and the effect of the E6-178G/E7-647G co-mutation was significantly greater than that of the single E7-647G mutant ( P <0.05). Conclusions： HPV16 E6-178G/E7-647G can thus promote the proliferation and inhibit the apoptosis of cervical cancer cells." @default.
- W4231781696 created "2022-05-12" @default.
- W4231781696 creator A5001076957 @default.
- W4231781696 creator A5013166864 @default.
- W4231781696 creator A5015005766 @default.
- W4231781696 creator A5016003737 @default.
- W4231781696 creator A5022200093 @default.
- W4231781696 creator A5037560724 @default.
- W4231781696 creator A5040779398 @default.
- W4231781696 creator A5048710749 @default.
- W4231781696 creator A5059651137 @default.
- W4231781696 creator A5062665642 @default.
- W4231781696 creator A5080515046 @default.
- W4231781696 date "2021-08-24" @default.
- W4231781696 modified "2023-09-29" @default.
- W4231781696 title "HPV16 E6-178G/E7-647G Promotes Proliferation and Inhibits Apoptosis in Cervical Cancer C33A Cells" @default.
- W4231781696 doi "https://doi.org/10.21203/rs.3.rs-153936/v2" @default.
- W4231781696 hasPublicationYear "2021" @default.
- W4231781696 type Work @default.
- W4231781696 citedByCount "0" @default.
- W4231781696 crossrefType "posted-content" @default.
- W4231781696 hasAuthorship W4231781696A5001076957 @default.
- W4231781696 hasAuthorship W4231781696A5013166864 @default.
- W4231781696 hasAuthorship W4231781696A5015005766 @default.
- W4231781696 hasAuthorship W4231781696A5016003737 @default.
- W4231781696 hasAuthorship W4231781696A5022200093 @default.
- W4231781696 hasAuthorship W4231781696A5037560724 @default.
- W4231781696 hasAuthorship W4231781696A5040779398 @default.
- W4231781696 hasAuthorship W4231781696A5048710749 @default.
- W4231781696 hasAuthorship W4231781696A5059651137 @default.
- W4231781696 hasAuthorship W4231781696A5062665642 @default.
- W4231781696 hasAuthorship W4231781696A5080515046 @default.
- W4231781696 hasBestOaLocation W42317816961 @default.
- W4231781696 hasConcept C104317684 @default.
- W4231781696 hasConcept C121608353 @default.
- W4231781696 hasConcept C143065580 @default.
- W4231781696 hasConcept C1491633281 @default.
- W4231781696 hasConcept C153911025 @default.
- W4231781696 hasConcept C185592680 @default.
- W4231781696 hasConcept C190283241 @default.
- W4231781696 hasConcept C2776415932 @default.
- W4231781696 hasConcept C2777366897 @default.
- W4231781696 hasConcept C2778220009 @default.
- W4231781696 hasConcept C2993195994 @default.
- W4231781696 hasConcept C502942594 @default.
- W4231781696 hasConcept C54009773 @default.
- W4231781696 hasConcept C54355233 @default.
- W4231781696 hasConcept C553184892 @default.
- W4231781696 hasConcept C62112901 @default.
- W4231781696 hasConcept C81885089 @default.
- W4231781696 hasConcept C86803240 @default.
- W4231781696 hasConceptScore W4231781696C104317684 @default.
- W4231781696 hasConceptScore W4231781696C121608353 @default.
- W4231781696 hasConceptScore W4231781696C143065580 @default.
- W4231781696 hasConceptScore W4231781696C1491633281 @default.
- W4231781696 hasConceptScore W4231781696C153911025 @default.
- W4231781696 hasConceptScore W4231781696C185592680 @default.
- W4231781696 hasConceptScore W4231781696C190283241 @default.
- W4231781696 hasConceptScore W4231781696C2776415932 @default.
- W4231781696 hasConceptScore W4231781696C2777366897 @default.
- W4231781696 hasConceptScore W4231781696C2778220009 @default.
- W4231781696 hasConceptScore W4231781696C2993195994 @default.
- W4231781696 hasConceptScore W4231781696C502942594 @default.
- W4231781696 hasConceptScore W4231781696C54009773 @default.
- W4231781696 hasConceptScore W4231781696C54355233 @default.
- W4231781696 hasConceptScore W4231781696C553184892 @default.
- W4231781696 hasConceptScore W4231781696C62112901 @default.
- W4231781696 hasConceptScore W4231781696C81885089 @default.
- W4231781696 hasConceptScore W4231781696C86803240 @default.
- W4231781696 hasLocation W42317816961 @default.
- W4231781696 hasOpenAccess W4231781696 @default.
- W4231781696 hasPrimaryLocation W42317816961 @default.
- W4231781696 hasRelatedWork W1539427268 @default.
- W4231781696 hasRelatedWork W2147761319 @default.
- W4231781696 hasRelatedWork W2347239577 @default.
- W4231781696 hasRelatedWork W2355259601 @default.
- W4231781696 hasRelatedWork W2368638395 @default.
- W4231781696 hasRelatedWork W2374725308 @default.
- W4231781696 hasRelatedWork W2378203004 @default.
- W4231781696 hasRelatedWork W2383829946 @default.
- W4231781696 hasRelatedWork W2386797884 @default.
- W4231781696 hasRelatedWork W2392484830 @default.
- W4231781696 isParatext "false" @default.
- W4231781696 isRetracted "false" @default.
- W4231781696 workType "article" @default.