Matches in SemOpenAlex for { <https://semopenalex.org/work/W4231824287> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W4231824287 endingPage "261" @default.
- W4231824287 startingPage "257" @default.
- W4231824287 abstract "This chapter reviews the pharmacological mechanisms and neuroprotective efficacy of tirilazad mesylate in experimental models of acute focal and global cerebral ischemia and subarachnoid hemorrhage (SAH) along with the results of several clinical neuroprotection trials. Tirilazad is one of the compounds of novel group of 21-aminosteroids (lazaroids), and is a potent inhibitor of oxygen radical-induced, iron-catalyzed lipid peroxidation (LP). Tirilazad is a very lipophilic compound that distributes preferentially to the lipid bilayer of cell membranes. Its anti-LP action includes cooperative mechanisms: a radical scavenging action and a physiochemical interaction with the cell membrane that serves to decrease membrane phospholipids fluidity. Due to its high affinity for cell membranes, tirilazad largely localizes in cerebrovascular endothelial membranes. Many of the actions of tirilazad in models of cerebral ischemia and SAH are reflective of its localization in endothelium. These include an attenuation of post-SAH microvascular hypoperfusion and delayed vasospasm. An important mechanism of these actions is based on tirilazad's demonstrated protection of endothelium-dependent relaxing factor production and/or function, which is known to be compromised during the LP injury associated with SAH." @default.
- W4231824287 created "2022-05-12" @default.
- W4231824287 creator A5076923638 @default.
- W4231824287 date "1997-01-01" @default.
- W4231824287 modified "2023-09-25" @default.
- W4231824287 title "21-Aminosteroids" @default.
- W4231824287 doi "https://doi.org/10.1016/b978-012743170-3/50075-3" @default.
- W4231824287 hasPublicationYear "1997" @default.
- W4231824287 type Work @default.
- W4231824287 citedByCount "0" @default.
- W4231824287 crossrefType "book-chapter" @default.
- W4231824287 hasAuthorship W4231824287A5076923638 @default.
- W4231824287 hasConcept C146957229 @default.
- W4231824287 hasConcept C164705383 @default.
- W4231824287 hasConcept C185592680 @default.
- W4231824287 hasConcept C202751555 @default.
- W4231824287 hasConcept C25498285 @default.
- W4231824287 hasConcept C2776120743 @default.
- W4231824287 hasConcept C2776151105 @default.
- W4231824287 hasConcept C2776820941 @default.
- W4231824287 hasConcept C2777736543 @default.
- W4231824287 hasConcept C2778506911 @default.
- W4231824287 hasConcept C2780829032 @default.
- W4231824287 hasConcept C42219234 @default.
- W4231824287 hasConcept C541997718 @default.
- W4231824287 hasConcept C55493867 @default.
- W4231824287 hasConcept C71924100 @default.
- W4231824287 hasConcept C98274493 @default.
- W4231824287 hasConceptScore W4231824287C146957229 @default.
- W4231824287 hasConceptScore W4231824287C164705383 @default.
- W4231824287 hasConceptScore W4231824287C185592680 @default.
- W4231824287 hasConceptScore W4231824287C202751555 @default.
- W4231824287 hasConceptScore W4231824287C25498285 @default.
- W4231824287 hasConceptScore W4231824287C2776120743 @default.
- W4231824287 hasConceptScore W4231824287C2776151105 @default.
- W4231824287 hasConceptScore W4231824287C2776820941 @default.
- W4231824287 hasConceptScore W4231824287C2777736543 @default.
- W4231824287 hasConceptScore W4231824287C2778506911 @default.
- W4231824287 hasConceptScore W4231824287C2780829032 @default.
- W4231824287 hasConceptScore W4231824287C42219234 @default.
- W4231824287 hasConceptScore W4231824287C541997718 @default.
- W4231824287 hasConceptScore W4231824287C55493867 @default.
- W4231824287 hasConceptScore W4231824287C71924100 @default.
- W4231824287 hasConceptScore W4231824287C98274493 @default.
- W4231824287 hasLocation W42318242871 @default.
- W4231824287 hasOpenAccess W4231824287 @default.
- W4231824287 hasPrimaryLocation W42318242871 @default.
- W4231824287 hasRelatedWork W129094610 @default.
- W4231824287 hasRelatedWork W2321915977 @default.
- W4231824287 hasRelatedWork W2361210040 @default.
- W4231824287 hasRelatedWork W2413781940 @default.
- W4231824287 hasRelatedWork W2465613368 @default.
- W4231824287 hasRelatedWork W2503224478 @default.
- W4231824287 hasRelatedWork W2760198213 @default.
- W4231824287 hasRelatedWork W2893250723 @default.
- W4231824287 hasRelatedWork W3030184024 @default.
- W4231824287 hasRelatedWork W3096507651 @default.
- W4231824287 isParatext "false" @default.
- W4231824287 isRetracted "false" @default.
- W4231824287 workType "book-chapter" @default.