Matches in SemOpenAlex for { <https://semopenalex.org/work/W4231837377> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W4231837377 endingPage "0862" @default.
- W4231837377 startingPage "0856" @default.
- W4231837377 abstract "Background: Inhaled nitric oxide (NO) is a rapidly acting selective pulmonary vasodilator that partially reverses the pathophysiology of acute respiratory distress syndrome (ARDS). Methods: After human studies approval, we studied 11 burned children with severe ARDS in a trial of inhaled NO therapy, assessing its effect on intrapulmonary shunt as measured by the PaO2/FiO2 ratio (PFR). There were 12 episodes of administration; 1 child was treated twice. Results: The children had an average age of 8.3 ± 4.8 years (mean ± SEM, range 11 months to 14 years) and average burn size of 64% ± 22%. At the time of enrollment, the PFR averaged 95 ± 50 and Murray lung score 3.1 ± 0.5. Inhaled NO was begun an average of 6.3 ± 5.5 days after injury and was administered for an average of 7.8 ± 7.2 days at an average dose of 6.7 ± 2.4 parts per million. PFR improved an average of 162% ± 214%. Eight of the 11 children (73%) survived. The 3 nonsurvivors had similar admission PFR values (100 ± 75 versus 93 ± 44, P = .089) but a significantly less favorable initial response to inhaled NO, with a percentage of improvement in PFR at 1 hour after enrollment of 7.3% ± 6.4% versus 213% ± 226% (P = .026). There were no complications related to NO administration. Conclusions: Inhaled NO can be safely administered to treat ARDS in children with acute burns and appears to improve their ventilatory management. An immediate improvement in PFR with inhaled NO may correlate with survival. (Surgery 1999;126:856-62.)" @default.
- W4231837377 created "2022-05-12" @default.
- W4231837377 creator A5008085561 @default.
- W4231837377 creator A5041976141 @default.
- W4231837377 creator A5054618559 @default.
- W4231837377 creator A5073059702 @default.
- W4231837377 date "1999-11-01" @default.
- W4231837377 modified "2023-09-27" @default.
- W4231837377 title "Low-dose inhaled nitric oxide in acutely burned children with profound respiratory failure" @default.
- W4231837377 doi "https://doi.org/10.1067/msy.2099.100382" @default.
- W4231837377 hasPublicationYear "1999" @default.
- W4231837377 type Work @default.
- W4231837377 citedByCount "1" @default.
- W4231837377 crossrefType "journal-article" @default.
- W4231837377 hasAuthorship W4231837377A5008085561 @default.
- W4231837377 hasAuthorship W4231837377A5041976141 @default.
- W4231837377 hasAuthorship W4231837377A5054618559 @default.
- W4231837377 hasAuthorship W4231837377A5073059702 @default.
- W4231837377 hasConcept C126322002 @default.
- W4231837377 hasConcept C141983124 @default.
- W4231837377 hasConcept C2776178081 @default.
- W4231837377 hasConcept C2776348555 @default.
- W4231837377 hasConcept C2776888751 @default.
- W4231837377 hasConcept C2776954882 @default.
- W4231837377 hasConcept C2777714996 @default.
- W4231837377 hasConcept C42219234 @default.
- W4231837377 hasConcept C519581460 @default.
- W4231837377 hasConcept C71924100 @default.
- W4231837377 hasConceptScore W4231837377C126322002 @default.
- W4231837377 hasConceptScore W4231837377C141983124 @default.
- W4231837377 hasConceptScore W4231837377C2776178081 @default.
- W4231837377 hasConceptScore W4231837377C2776348555 @default.
- W4231837377 hasConceptScore W4231837377C2776888751 @default.
- W4231837377 hasConceptScore W4231837377C2776954882 @default.
- W4231837377 hasConceptScore W4231837377C2777714996 @default.
- W4231837377 hasConceptScore W4231837377C42219234 @default.
- W4231837377 hasConceptScore W4231837377C519581460 @default.
- W4231837377 hasConceptScore W4231837377C71924100 @default.
- W4231837377 hasIssue "5" @default.
- W4231837377 hasLocation W42318373771 @default.
- W4231837377 hasOpenAccess W4231837377 @default.
- W4231837377 hasPrimaryLocation W42318373771 @default.
- W4231837377 hasRelatedWork W1965690853 @default.
- W4231837377 hasRelatedWork W1990841211 @default.
- W4231837377 hasRelatedWork W2000389985 @default.
- W4231837377 hasRelatedWork W2022998036 @default.
- W4231837377 hasRelatedWork W2026996696 @default.
- W4231837377 hasRelatedWork W2031138735 @default.
- W4231837377 hasRelatedWork W2057768267 @default.
- W4231837377 hasRelatedWork W2271075549 @default.
- W4231837377 hasRelatedWork W4237087697 @default.
- W4231837377 hasRelatedWork W4302550774 @default.
- W4231837377 hasVolume "126" @default.
- W4231837377 isParatext "false" @default.
- W4231837377 isRetracted "false" @default.
- W4231837377 workType "article" @default.