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- W4231856471 abstract "Obsessive-compulsive disorder is defined by the presence of obsessions and compulsions that cause marked anxiety or distress and has been associated with a disruption in cortico-striato-thalamo-cortical circuitry. After treatment, around 50% of patients continue to experience incapacitating symptoms. Deep-brain stimulation has been shown to be an effective therapeutic alternative to regular treatment. Case report. A 54-year-old woman with a diagnosis of treatment-resistant obsessive-compulsive disorder was treated with deep-brain stimulation of the anterior limb of the internal capsule. Molecular imaging before and after the procedure was obtained and correlated with clinical features. Deep-brain stimulation may be a therapeutic alternative to regular care in treatment-resistant obsessive-compulsive disorder and can be correlated to functional changes in suspected anatomical structures. El trastorno obsesivo-compulsivo se define por la presencia de obsesiones y compulsiones que ocasionan ansiedad y malestar marcados, y se ha asociado con una alteración en los circuitos cortico-estriado-tálamo-corticales. Tras tratamiento, alrededor de la mitad de los pacientes permanecen con síntomas discapacitantes. La estimulación cerebral profunda ha mostrado ser una alternativa efectiva al tratamiento usual. Reporte de caso. Una mujer de 54 años con diagnóstico de trastorno obsesivo-compulsivo resistente a tratamiento fue tratada con estimulación cerebral profunda del brazo anterior de la cápsula interna. Se obtuvieron imágenes moleculares antes y después de la intervención y fueron correlacionadas con el cuadro clínico. La estimulación magnética profunda puede ser una alternativa terapéutica al tratamiento usual en el trastorno obsesivo compulsivo resistente a tratamiento, y puede correlacionarse con cambios funcionales en estructuras anatómicas de sospecha." @default.
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- W4231856471 date "2020-01-01" @default.
- W4231856471 modified "2023-10-17" @default.
- W4231856471 title "Deep-brain stimulation in treatment-resistant obsessive-compulsive disorder: Clinical and molecular neuroimaging correlation" @default.
- W4231856471 doi "https://doi.org/10.1016/j.rcpeng.2018.05.004" @default.
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