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- W4231868605 abstract "Infusions of Chenopodium ambrosioides (L.) have been used for centuries in the Americas as a popular remedy against intestinal worm infections. The essential oil of Chenopodium ambrosioides contains high levels of ascaridole, which is a potent anthelmintic, but which has also been responsible for human fatalities, leading to its disuse. Almost 90% of the nematocidal activity of Chenopodium ambrosioides infusions was due to a hydrophilic component different from ascaridole. Synthetic ascaridole and the ascaridole from infusions, extracted into hexane, caused a reduction of carbachol-induced contractions in rat gastrointestinal smooth muscle at concentrations required to kill Caenorhabditis elegans (L.). The herbal infusion and the ascaridole-free hexane-extracted aqueous residue of the above infusion, at nematocidal concentractions, had no detectable effect on smooth muscle contraction in the above system. It would appear that the traditional form of useage of Chenopodium ambrosioides infusions as a vermifuge is safer than the use of the herb’s essential oil." @default.
- W4231868605 created "2022-05-12" @default.
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- W4231868605 date "2004-06-01" @default.
- W4231868605 modified "2023-09-27" @default.
- W4231868605 title "Ascaridole-less infusions of Chenopodium ambrosioides contain a nematocide(s) that is(are) not toxic to mammalian smooth muscle" @default.
- W4231868605 doi "https://doi.org/10.1016/s0378-8741(04)00079-0" @default.
- W4231868605 hasPublicationYear "2004" @default.
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