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• W4231874606 abstract "Caspase-3 is a cysteinyl protease that mediates apoptotic cell death. Its inhibition may have an important impact in the treatment of several degenerative diseases. Since P(1) aspartic acid is a required element of recognition for this enzyme, a library of capped aspartyl aldehydes was synthesized using solid-phase chemistry. The 5-bromonicotinamide derivative of the aspartic acid aldehyde was identified to be an inhibitor of caspase-3. Substitution at the 5-position of the pyridine ring and conversion of the aldehyde to ketones led to a series of potent inhibitors of caspase-3." @default.
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• W4231874606 date "2003-07-01" @default.
• W4231874606 modified "2023-10-03" @default.
• W4231874606 title "Nicotinyl aspartyl ketones as inhibitors of caspase-3" @default.
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• W4231874606 doi "https://doi.org/10.1016/s0960-894x(03)00390-1" @default.
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