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- W4231961521 abstract "Forty years ago the fluorinated form of the pyrimidine nucleobase uracil was described as an anticancer drug for the first time. It has since been used in the treatment of a variety of human cancers and is now an established drug alone or in combination with other agents for the treatment of gastrointestinal tract cancer, breast cancer and several squamous cell cancers. In the late 1970s new technical developments led to the elucidation of the mechanisms by which 5-fluorouracil (5-FU) exerts its effects. This opened ways to influence and improve these effects by the addition of modulating agents. In general, these agents are supposed to supply substrates or to inhibit competitively degrading enzymes. A number of substances have been shown to improve the effects of 5-FU on rodent and human tumour cell lines in vitro." @default.
- W4231961521 created "2022-05-12" @default.
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- W4231961521 date "1999-02-01" @default.
- W4231961521 modified "2023-09-27" @default.
- W4231961521 title "Does biomodulation of 5-fluorouracil improve results?" @default.
- W4231961521 doi "https://doi.org/10.1016/s0959-8049(98)00363-3" @default.
- W4231961521 hasPublicationYear "1999" @default.
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