FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4231976120> ?p ?o ?g. }

• W4231976120 endingPage "34" @default.
• W4231976120 startingPage "31" @default.
• W4231976120 abstract "Tensin is a cytoplasmic phosphoprotein that localized to integrin-mediated focal adhesions. It binds to actin filaments and contains a phosphotyrosine-binding (PTB) domain, which interacts with the cytoplasmic tails of β integrin. These interactions allow tensin to link actin filaments to integrin receptors. In addition, tensin has an Src Homology 2 (SH2) domain capable of interacting with tyrosine-phosphorylated proteins. Furthermore, several factors induce tyrosine phosphorylation of tensin. Thus, tensin functions as a platform for dis/assembly of signaling complexes at focal adhesions by recruiting tyrosine-phosphorylated signaling molecules through the SH2 domain, and also by providing interaction sites for other SH2-containing proteins. Analysis of knockout mice has demonstrated critical roles of tensin in renal function, muscle regeneration, and cell migration. Therefore, tensin and its downstream signaling molecules may be targets for therapeutic interventions in renal disease, wound healing and cancer." @default.
• W4231976120 created "2022-05-12" @default.
• W4231976120 creator A5035127037 @default.
• W4231976120 date "2004-01-01" @default.
• W4231976120 modified "2023-10-16" @default.
• W4231976120 title "Tensin" @default.
• W4231976120 cites W1524910418 @default.
• W4231976120 cites W1550235641 @default.
• W4231976120 cites W1974014017 @default.
• W4231976120 cites W1982754674 @default.
• W4231976120 cites W1988626066 @default.
• W4231976120 cites W1990883677 @default.
• W4231976120 cites W2002571173 @default.
• W4231976120 cites W2007349364 @default.
• W4231976120 cites W2029231027 @default.
• W4231976120 cites W2053001031 @default.
• W4231976120 cites W2085154580 @default.
• W4231976120 cites W2139110735 @default.
• W4231976120 cites W2161142484 @default.
• W4231976120 cites W2167078135 @default.
• W4231976120 cites W4254071221 @default.
• W4231976120 doi "https://doi.org/10.1016/s1357-2725(03)00171-7" @default.
• W4231976120 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14592531" @default.
• W4231976120 hasPublicationYear "2004" @default.
• W4231976120 type Work @default.
• W4231976120 citedByCount "163" @default.
• W4231976120 countsByYear W42319761202012 @default.
• W4231976120 countsByYear W42319761202013 @default.
• W4231976120 countsByYear W42319761202014 @default.
• W4231976120 countsByYear W42319761202015 @default.
• W4231976120 countsByYear W42319761202016 @default.
• W4231976120 countsByYear W42319761202017 @default.
• W4231976120 countsByYear W42319761202018 @default.
• W4231976120 countsByYear W42319761202019 @default.
• W4231976120 countsByYear W42319761202020 @default.
• W4231976120 countsByYear W42319761202021 @default.
• W4231976120 countsByYear W42319761202022 @default.
• W4231976120 countsByYear W42319761202023 @default.
• W4231976120 crossrefType "journal-article" @default.
• W4231976120 hasAuthorship W4231976120A5035127037 @default.
• W4231976120 hasConcept C108636557 @default.
• W4231976120 hasConcept C116581196 @default.
• W4231976120 hasConcept C11960822 @default.
• W4231976120 hasConcept C142669718 @default.
• W4231976120 hasConcept C1491633281 @default.
• W4231976120 hasConcept C151166631 @default.
• W4231976120 hasConcept C170493617 @default.
• W4231976120 hasConcept C185592680 @default.
• W4231976120 hasConcept C195687474 @default.
• W4231976120 hasConcept C197153747 @default.
• W4231976120 hasConcept C2777553839 @default.
• W4231976120 hasConcept C2777609662 @default.
• W4231976120 hasConcept C2779549131 @default.
• W4231976120 hasConcept C2993400109 @default.
• W4231976120 hasConcept C502942594 @default.
• W4231976120 hasConcept C55493867 @default.
• W4231976120 hasConcept C62478195 @default.
• W4231976120 hasConcept C85528070 @default.
• W4231976120 hasConcept C86333721 @default.
• W4231976120 hasConcept C86554907 @default.
• W4231976120 hasConcept C86803240 @default.
• W4231976120 hasConcept C95444343 @default.
• W4231976120 hasConceptScore W4231976120C108636557 @default.
• W4231976120 hasConceptScore W4231976120C116581196 @default.
• W4231976120 hasConceptScore W4231976120C11960822 @default.
• W4231976120 hasConceptScore W4231976120C142669718 @default.
• W4231976120 hasConceptScore W4231976120C1491633281 @default.
• W4231976120 hasConceptScore W4231976120C151166631 @default.
• W4231976120 hasConceptScore W4231976120C170493617 @default.
• W4231976120 hasConceptScore W4231976120C185592680 @default.
• W4231976120 hasConceptScore W4231976120C195687474 @default.
• W4231976120 hasConceptScore W4231976120C197153747 @default.
• W4231976120 hasConceptScore W4231976120C2777553839 @default.
• W4231976120 hasConceptScore W4231976120C2777609662 @default.
• W4231976120 hasConceptScore W4231976120C2779549131 @default.
• W4231976120 hasConceptScore W4231976120C2993400109 @default.
• W4231976120 hasConceptScore W4231976120C502942594 @default.
• W4231976120 hasConceptScore W4231976120C55493867 @default.
• W4231976120 hasConceptScore W4231976120C62478195 @default.
• W4231976120 hasConceptScore W4231976120C85528070 @default.
• W4231976120 hasConceptScore W4231976120C86333721 @default.
• W4231976120 hasConceptScore W4231976120C86554907 @default.
• W4231976120 hasConceptScore W4231976120C86803240 @default.
• W4231976120 hasConceptScore W4231976120C95444343 @default.
• W4231976120 hasIssue "1" @default.
• W4231976120 hasLocation W42319761201 @default.
• W4231976120 hasLocation W42319761202 @default.
• W4231976120 hasOpenAccess W4231976120 @default.
• W4231976120 hasPrimaryLocation W42319761201 @default.
• W4231976120 hasRelatedWork W1963784281 @default.
• W4231976120 hasRelatedWork W2000348274 @default.
• W4231976120 hasRelatedWork W2003044215 @default.
• W4231976120 hasRelatedWork W2007424354 @default.
• W4231976120 hasRelatedWork W2019386067 @default.
• W4231976120 hasRelatedWork W2067414711 @default.
• W4231976120 hasRelatedWork W2093762625 @default.
• W4231976120 hasRelatedWork W2119920331 @default.
• W4231976120 hasRelatedWork W2153936778 @default.

• next