Matches in SemOpenAlex for { <https://semopenalex.org/work/W4231992210> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W4231992210 abstract "Abstract Background: Patients taking opioids are known to develop opioid-induced constipation (OIC), which reduces their quality of life (QOL). The aim of this study is to compare magnesium oxide and naldemedine to determine which is more effective in preventing OIC. Methods: This is a proof of concept, prospective, randomized controlled trial, conducted in Japan in March 2018. Initially, a questionnaire survey will be carried out targeting adult cancer patients who had concomitantly commenced opioid and OIC prevention treatment. Patients will then be randomly allocated into a magnesium oxide (500 mg, tid) group or a naldemedine (0.2 mg, sid) group. Each drug will be orally administrated for 12 weeks. The primary endpoint is defined as any improvement in the Japanese version of Patient Assessment of Constipation Quality of Life (JPAC-QOL) scores from the baseline to 2 weeks of treatment. Discussion: The primary endpoint is changes in the JPAC-QOL scores from the baseline to 2 weeks of intervention. The key secondary endpoint will be changes in spontaneous bowel movements (SBMs) at 2 and 12 weeks of intervention. This study will determine whether magnesium oxide or naldemedine is more effective for the prevention of OIC.Trial registration: This trial is registered in the University Hospital Medical Information Network (UMIN) Clinical Trials Registry (UMIN000031891). Registered 25 March 2018, https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000036408." @default.
- W4231992210 created "2022-05-12" @default.
- W4231992210 creator A5003648443 @default.
- W4231992210 creator A5003859363 @default.
- W4231992210 creator A5015408047 @default.
- W4231992210 creator A5021468178 @default.
- W4231992210 creator A5028348117 @default.
- W4231992210 creator A5028685228 @default.
- W4231992210 creator A5034628858 @default.
- W4231992210 creator A5037018317 @default.
- W4231992210 creator A5041516803 @default.
- W4231992210 creator A5052478205 @default.
- W4231992210 creator A5057141925 @default.
- W4231992210 creator A5067227542 @default.
- W4231992210 creator A5071808903 @default.
- W4231992210 creator A5074810793 @default.
- W4231992210 creator A5086386473 @default.
- W4231992210 creator A5087166136 @default.
- W4231992210 creator A5090765558 @default.
- W4231992210 date "2019-08-12" @default.
- W4231992210 modified "2023-09-27" @default.
- W4231992210 title "Comparing the effectiveness of magnesium oxide and naldemedine in preventing opioid-induced constipation: A proof of concept, single institutional, two arm, open-label, phase II, randomized controlled trial: the MAGNET study" @default.
- W4231992210 doi "https://doi.org/10.21203/rs.2.12623/v1" @default.
- W4231992210 hasPublicationYear "2019" @default.
- W4231992210 type Work @default.
- W4231992210 citedByCount "0" @default.
- W4231992210 crossrefType "posted-content" @default.
- W4231992210 hasAuthorship W4231992210A5003648443 @default.
- W4231992210 hasAuthorship W4231992210A5003859363 @default.
- W4231992210 hasAuthorship W4231992210A5015408047 @default.
- W4231992210 hasAuthorship W4231992210A5021468178 @default.
- W4231992210 hasAuthorship W4231992210A5028348117 @default.
- W4231992210 hasAuthorship W4231992210A5028685228 @default.
- W4231992210 hasAuthorship W4231992210A5034628858 @default.
- W4231992210 hasAuthorship W4231992210A5037018317 @default.
- W4231992210 hasAuthorship W4231992210A5041516803 @default.
- W4231992210 hasAuthorship W4231992210A5052478205 @default.
- W4231992210 hasAuthorship W4231992210A5057141925 @default.
- W4231992210 hasAuthorship W4231992210A5067227542 @default.
- W4231992210 hasAuthorship W4231992210A5071808903 @default.
- W4231992210 hasAuthorship W4231992210A5074810793 @default.
- W4231992210 hasAuthorship W4231992210A5086386473 @default.
- W4231992210 hasAuthorship W4231992210A5087166136 @default.
- W4231992210 hasAuthorship W4231992210A5090765558 @default.
- W4231992210 hasBestOaLocation W42319922101 @default.
- W4231992210 hasConcept C126322002 @default.
- W4231992210 hasConcept C159110408 @default.
- W4231992210 hasConcept C168563851 @default.
- W4231992210 hasConcept C203092338 @default.
- W4231992210 hasConcept C2779951463 @default.
- W4231992210 hasConcept C2781112942 @default.
- W4231992210 hasConcept C3019800554 @default.
- W4231992210 hasConcept C535046627 @default.
- W4231992210 hasConcept C71924100 @default.
- W4231992210 hasConceptScore W4231992210C126322002 @default.
- W4231992210 hasConceptScore W4231992210C159110408 @default.
- W4231992210 hasConceptScore W4231992210C168563851 @default.
- W4231992210 hasConceptScore W4231992210C203092338 @default.
- W4231992210 hasConceptScore W4231992210C2779951463 @default.
- W4231992210 hasConceptScore W4231992210C2781112942 @default.
- W4231992210 hasConceptScore W4231992210C3019800554 @default.
- W4231992210 hasConceptScore W4231992210C535046627 @default.
- W4231992210 hasConceptScore W4231992210C71924100 @default.
- W4231992210 hasLocation W42319922101 @default.
- W4231992210 hasLocation W42319922102 @default.
- W4231992210 hasLocation W42319922103 @default.
- W4231992210 hasOpenAccess W4231992210 @default.
- W4231992210 hasPrimaryLocation W42319922101 @default.
- W4231992210 hasRelatedWork W2142215226 @default.
- W4231992210 hasRelatedWork W2583288609 @default.
- W4231992210 hasRelatedWork W2589767772 @default.
- W4231992210 hasRelatedWork W2887282919 @default.
- W4231992210 hasRelatedWork W2899353411 @default.
- W4231992210 hasRelatedWork W2955643247 @default.
- W4231992210 hasRelatedWork W2959603226 @default.
- W4231992210 hasRelatedWork W2998951754 @default.
- W4231992210 hasRelatedWork W3163371109 @default.
- W4231992210 hasRelatedWork W4367053521 @default.
- W4231992210 isParatext "false" @default.
- W4231992210 isRetracted "false" @default.
- W4231992210 workType "article" @default.